Anti-pd-l1 antibodies
AssigneeIGM Biosciences, Inc.
InventorsBruce KEYT, Leonard George PRESTA, Ramesh BALIGA
Life of this patent
Estimating the term…
Abstract
Aspects of the invention include isolated anti-PD-L1 antibodies, as well as compositions containing such antibodies, and methods of using the same in the treatment of diseases or conditions that are mediated by PD-L1 signaling.
Claims31
An isolated anti-PD-L1 antibody, or an antigen-binding fragment thereof, comprising a heavy chain variable region (VH) and a light chain variable region (VL), wherein the antibody or antigen-binding fragment thereof comprises:
- (i) an HVR-H1 sequence having at least about 99% sequence identity to the sequence of GFSLTSYDIS (SEQ ID NO:
- 4);
- (ii) an HVR-H2 sequence having at least about 99% sequence identity to the sequence of VIWTGVGTN (SEQ ID NO:
- 5);
- and
- (iii) an HVR-H3 sequence having at least about 99% sequence identity to the sequence of DPYYYGMDY (SEQ ID NO:
- 6);
- (iv) an HVR-L1 comprising at least about 99% sequence identity to the sequence of RASQDISIWLS (SEQ ID NO:
- 1);
- (v) an HVR-L2 comprising at least about 99% sequence identity to the sequence of KASNLHT (SEQ ID NO:
- 2);
- and
- (vi) HVR-L3 comprising at least about 99% sequence identity to the sequence of LQSQSFPRT (SEQ ID NO:
- 3).
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An isolated anti-PD-L1 antibody or an antigen-binding fragment thereof, comprising a VH having at least 90% sequence identity to SEQ ID NO:
- 45 and a VL having at least 90% sequence identity to SEQ ID NO:
- 46.
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An isolated anti-PD-L1 antibody or antigen-binding fragment thereof, comprising a VH having at least 90% sequence identity to any one of SEQ ID NOS:
- 36, 37, 38, 39, 40, 41 or 42 and a VL having at least 90% sequence identity to any one of SEQ ID NOS:
- 43 or 44.
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Dependencies are inferred from the claim text.