Methods and compositions for treating chronic obstructive pulmonary disorder
AssigneeAllakos Inc.
InventorsBradford Andrew YOUNGBLOOD, Nenad TOMASEVIC, Christopher Robert BEBBINGTON
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Abstract
The present disclosure provides methods for the treatment of chronic obstructive pulmonary disease (COPD) (e.g., non-eosinophilic COPD). In particular, the present disclosure provides methods for the treatment of COPD (e.g., non-eosinophilic COPD) through administration of antibodies that bind to human Siglec-8 or compositions comprising said antibodies. The present disclosure also provides articles of manufacture or kits comprising antibodies that bind to human Siglec-8 for the treatment of COPD (e.g., non-eosinophilic COPD).
Claims39
A method for treating chronic obstructive pulmonary disease (COPD) in an individual comprising administering to the individual an effective amount of an antibody that binds to human Siglec-8, wherein the individual has non-eosinophilic COPD.
A method for treating chronic obstructive pulmonary disease (COPD) in an individual comprising administering to the individual an effective amount of an antibody that binds to human Siglec-8, wherein an induced sputum sample from the individual contains greater than about 70% neutrophils relative to total leukocyte content.
Dependencies are inferred from the claim text.