Antibody fragments for the treatment of biofilm-related disorders
AssigneeResearch Institute At Nationwide Children's Hospital
InventorsLauren O. Bakaletz, Steven D. Goodman
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Abstract
This disclosure provides antibody fragments and isolated polypeptides comprising the antibody fragments that are useful as a therapeutic for those with an existing infection characterized by the formation of biofilms. Antibody fragments and isolated polypeptides comprising the antibody fragments can be administered to detect, treat, or prevent infection and/or remediate biofilms. Bacteria that cannot form functional biofilms are more readily cleared by the remainder of the host's immune system and/or traditional antibiotics.
Claims33
A method to treat or prevent an inflammatory response related to an infection with a microorganism that produces a DNABII protein in a subject, or treat a subject infected with a biofilm or suffering from a condition associated with the presence of a biofilm, the method comprising administering to the subject an effective amount of an antibody Fab fragment, wherein the antibody specifically binds a DNABII protein or an equivalent thereof, and further wherein the antibody Fab fragment induces the production of anti-inflammatory cytokines in the subject.
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An isolated polypeptide comprising a Fab fragment of an mIhfB4NTHI antibody or an equivalent of the polypeptide.
An isolated polypeptide consisting essentially of a Fab fragment of an mIhfB4NTHI antibody, or an equivalent of the polypeptide.
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Dependencies are inferred from the claim text.