Fusion peptides with antigens linked to short fragments of invariant chain(cd74)

A fusion protein, comprising a polypeptide, wherein the polypeptide consists of a fragment of an invariant chain which is operably linked to an antigenic sequence, and wherein the fragment of invariant chain consists of:

• (a) a portion of residues 17-97 of SEQ ID NO:
• 1, wherein the portion comprises at least 5 contiguous residues from residues 77-92 of SEQ ID NO:
• 1;
• (b) 80 residues or fewer and comprises a sequence of at least 5 contiguous residues wherein the sequence shares at least 80% identity with at least 5 contiguous residues from residues 77-92 of SEQ ID NO:
• 1;
• (c) residues 1-97 of SEQ ID NO:
• 1;
• (d) 91 to 103 residues and shares at least 95% identity with residues 1-97 of SEQ ID NO:
• 1;
• (e) residues 17-97 of SEQ ID NO:
• 1;
• (f) 76 to 84 residues and shares at least 95% identity with residues 17-97 of SEQ ID NO:
• 1;
• (g) residues 1-92 of SEQ ID NO:
• 1;
• (h) 88 to 96 residues and shares at least 95% identity with residues 1-92 of SEQ ID NO:
• 1;
• (i) residues 17-92 of SEQ ID NO:
• 1;
• or
• (j) 71 to 79 residues and shares at least 95% identity with residues 17-92 of SEQ ID NO:
• 1.

A polynucleotide encoding a fusion protein, which comprises a polypeptide, wherein the polypeptide consists of a fragment of an invariant chain which is operably linked to an antigenic sequence, and wherein the fragment of invariant chain consists of:

• (a) a portion of residues 17-97 of SEQ ID NO:
• 1, wherein the portion comprises at least 5 contiguous residues from residues 77-92 of SEQ ID NO:
• 1;
• (b) 80 residues or fewer and comprises a sequence of at least 5 contiguous residues wherein the sequence shares at least 80% identity with at least 5 contiguous residues from residues 77-92 of SEQ ID NO:
• 1;
• (c) residues 1-97 of SEQ ID NO:
• 1;
• (d) 91 to 103 residues and shares at least 95% identity with residues 1-97 of SEQ ID NO:
• 1;
• (e) residues 17-97 of SEQ ID NO:
• 1;
• (f) 76 to 84 residues and shares at least 95% identity with residues 17-97 of SEQ ID NO:
• 1;
• (g) residues 1-92 of SEQ ID NO:
• 1;
• (h) 88 to 96 residues and shares at least 95% identity with residues 1-92 of SEQ ID NO:
• 1;
• (i) residues 17-92 of SEQ ID NO:
• 1;
• or
• (j) 71 to 79 residues and shares at least 95% identity with residues 17-92 of SEQ ID NO:
• 1.

A viral vector, comprising a polynucleotide encoding a fusion protein, which comprises a polypeptide, wherein the polypeptide consists of a fragment of invariant chain which is operably linked to an antigenic sequence and wherein the fragment of invariant chain consists of:

• (a) a portion of residues 17-97 of SEQ ID NO:
• 1, wherein the portion comprises at least 5 contiguous residues from residues 77-92 of SEQ ID NO:
• 1;
• (b) 80 residues or fewer and comprises a sequence of at least 5 contiguous residues wherein the sequence shares at least 80% identity with at least 5 contiguous residues from residues 77-92 of SEQ ID NO:
• 1;
• (c) residues 1-97 of SEQ ID NO:
• 1;
• (d) 91 to 103 residues and shares at least 95% identity with residues 1-97 of SEQ ID NO:
• 1;
• (e) residues 17-97 of SEQ ID NO:
• 1;
• (f) 76 to 84 residues and shares at least 95% identity with residues 17-97 of SEQ ID NO:
• 1;
• (g) residues 1-92 of SEQ ID NO:
• 1;
• (h) 88 to 96 residues and shares at least 95% identity with residues 1-92 of SEQ ID NO:
• 1;
• (i) residues 17-92 of SEQ ID NO:
• 1;
• or
• (j) 71 to 79 residues and shares at least 95% identity with residues 17-92 of SEQ ID NO:
• 1.