Composition Containing SMAD Protein for Treatment of Autoimmune Diseases, a Fusion Protein Comprising SMAD Protein, an Expression Vector and a Method for Preparing the Same
AssigneeGood T Cells, Inc.
InventorsSang-Kyou Lee, Sung-Dong Park, Sang Won Lee, Chin Hee Mun
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Abstract
The present invention relates to a composition and a fusion protein for prevention or treatment of autoimmune diseases, which contain a Smad protein, and provides a method for prevention or treatment of autoimmune diseases, including lupus nephritis and rheumatoid arthritis.
Claims15
-25. (canceled)
An expression vector comprising a nucleic acid sequence that encodes the fusion protein comprising a Smad3 protein or a Smad3 transcription modulation domain protein;
- and a protein transduction domain, wherein Smad3 protein comprises an amino acid sequence of SEQ ID NO:
- 1 and the Smad3 transcription modulation domain protein comprises an amino acid sequence of SEQ ID NO:
- 3.
A recombinant host cell overexpressing an exogenous nucleic acid sequence that encodes the fusion protein comprising a Smad3 protein or a Smad3 transcription modulation domain protein;
- and a protein transduction domain, wherein Smad3 protein comprises an amino acid sequence of SEQ ID NO:
- 1 and the Smad3 transcription modulation domain protein comprises an amino acid sequence of SEQ ID NO:
- 3.
A method for treating an autoimmune disease, comprising:
- administering a fusion protein comprising:
- a Smad3 protein or a Smad3 transcription modulation domain protein;
- and a protein transduction domain, wherein Smad3 protein comprises an amino acid sequence of SEQ ID NO:
- 1 and the Smad3 transcription modulation domain protein comprises an amino acid sequence of SEQ ID NO:
- 3 to a subject in need.
Dependencies are inferred from the claim text.