US 2019/0337997 A1 · MODIFIED PEPTIDES

Abstract

The present invention relates to the field of antimicrobial agents. In particular, the present invention relates to polypeptides comprising the sequence of a peptidoglycan hydrolase and a peptide sequence heterologous to the peptidoglycan hydrolase wherein said heterologous peptide sequence comprises a specific sequence motif which is 16, 17, 18, 19 or 20 amino acids in length. The present invention relates also to corresponding nucleic acids, vectors, bacteriophages, host cells, compositions and kits. The present inventions also relates to the use of said polypeptides, nucleic acids, vectors, bacteriophages, host cells, compositions and kits in methods for treatment of the human or animal body by surgery or therapy or in diagnostic methods practiced on the human or animal body. The polypeptides, nucleic acids, vectors, bacteriophages, host cells, compositions and kits according to the invention may also be used as an antimicrobial in, e.g., food or feed, in cosmetics, or as disinfecting agent.

Claims34

Dependent claims

A polypeptide comprising:

i) the CHAP domain of LysK endolysin or a variant thereof exhibiting at least 80% sequence identity with the CHAP domain of LysK endolysin;
ii) the M23 endopeptidase domain of lysostaphin or a variant thereof exhibiting at least 80% sequence identity with the M23 endopeptidase domain of lysostaphin;
iii) the cell wall binding domain (CBD) of ALE-1 or a variant thereof exhibiting at least 90% sequence identity with the cell wall binding domain (CBD) of ALE-1, and
iv) a further peptide selected from the group consisting of an antimicrobial peptide, an amphipathic peptide, a cationic peptide, a hydrophobic peptide, a sushi peptide and a defensin.

1 more element

Dependencies are inferred from the claim text.

Modified peptides

Life of this patent

Modified peptides

Life of this patent

Abstract

Claims34