Dnabii vaccines and antibodies with enhanced activity
AssigneeResearch Institute At Nationwide Children's Hospital
InventorsLauren O. Bakaletz, Steven D. Goodman
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Abstract
The disclosure provides methods and compositions that are useful to lessen and/or cure bacterial biofilms and treat diseases or disorders associated with biofilms using one or more novel polypeptide vaccines, antibodies, antibody fragments and compositions. Bacteria that cannot form functional biofilms are more readily cleared by the remainder of the host's immune system and/or traditional antibiotics.
Claims35
A recombinant polypeptide comprising two or more isolated conformational tip domains of a DNABII polypeptide or a fragment or a biological equivalent of one or more of the conformational tip domains.
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A recombinant polypeptide comprising a sequence encoded by SEQ ID NO:
- 12 (FLEEIRLSLESGQDVKLSGF) and a sequence encoded by SEQ ID NO:
- 15 (TLSAKEIENMVKDILEFISQ) joined via a linker polypeptide comprising a sequence encoded by SEQ ID NO:
- 44 (GPSL).
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Dependencies are inferred from the claim text.