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US 2019/0337988 A1Published application
Novel transporter constructs and transporter cargo conjugate molecules
AssigneeXigen Inflammation Ltd.
InventorChristophe Bonny
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Abstract
The present invention relates to novel transporter constructs of the generic formula (I) DlLLLxDm(LLLyDn)a and variants thereof. The present invention also refers to transporter cargo conjugate molecules, particularly of conjugates of the novel transporter constructs with a cargo moiety, e.g. proteins or peptides, nucleic acids, cytotoxic agents, organic molecules, etc. The present invention furthermore discloses (pharmaceutical) compositions comprising these conjugates and methods of treatment and uses involving such transporter constructs.
Claims15
A transport cargo conjugate molecule comprising
- a) a component (A) comprising a transporter construct comprising a sequence selected from the group consisting of an amino acid sequence comprising rKKRrQRRr (SEQ ID NO:20) and an amino acid sequence comprising rRRQrRKKr (SEQ ID NO:21), wherein lowercase designations indicate D-amino acids and uppercase designations indicate L-amino acids;
- and
- b) a component (B) comprising an effector molecule.
Dependencies are inferred from the claim text.