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US 2019/0337983 A1Published application
Oral peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory bowel diseases
AssigneeProtagonist Therapeutics, Inc.
InventorsAshok Bhandari, Gregory Thomas BOURNE, Xiaoli Cheng, Brian Troy Frederick, Jie Zhang, Dinesh V. Patel, David Liu
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Abstract
Peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of diseases and disorders, including inflammatory bowel disease, are disclosed.
Claims4
A peptide inhibitor of an interleukin-23 receptor, or a pharmaceutically acceptable salt or solvate thereof, wherein the peptide inhibitor comprises an amino acid sequence of Formula (Xa):
- X1-X2-X3-X4-X5-X6-X7-X8-X9-X10-X11-X12-X13-X14-X15-X16-X17-X18-X19-X20 (Xa)
- wherein
- X1 is any amino acid or absent;
- X2 is any amino acid or absent;
- X3 is any amino acid or absent;
- X4 is any amino acid or chemical moiety capable of forming a bond with X9;
- X5 is any amino acid;
- X6 is any amino acid;
- X7 is any amino acid;
- X8 is any amino acid;
- X9 is any amino acid or chemical moiety capable of forming a bond with X4;
- X10 is any amino acid;
- X11 is any amino acid;
- X12 is any amino acid;
- X13 is any amino acid;
- X14 is any amino acid;
- X15 is any amino acid,
- X16 is any amino acid or absent;
- X17 is any amino acid or absent;
- X18 is any amino acid or absent;
- X19 is any amino acid or absent;
- and
- X20 is any amino acid or absent,
- wherein the peptide inhibitor is cyclized via a bond between X4 and X9, and
- wherein the peptide inhibitor inhibits the binding of an interleukin-23 (IL-23) to an IL-23 receptor.
22 more elements
-46. (canceled)
-54. (canceled)
Dependencies are inferred from the claim text.