Peptidic protein kinase c inhibitors and uses thereof

A peptide of 5 to 10 amino acids in total of the following Formula (I):

• Z—Z1-Xaa4Xaa5RXaa7Xaa8-Z2 (I)
• wherein Z is a cell penetrating moiety;
• Z1 is an optional peptidic moiety of 1 to 3 amino acids of formula (II):
• Xaa1Xaa2Xaa3 (II)
• wherein Xaa1 and Xaa2 can be present or absent and, when present, Xaa1 and Xaa2 are independently a positively charged amino acid and Xaa3 is a non-polar amino acid;
• Xaa4 is an amino acid selected from Ala, Ser and Val;
• R is Arginine;
• Xaa5 and Xaa8 are independently a positively charged amino acid;
• Xaa7 is a non-polar amino acid Z2 is an optional peptidic moiety of 1 to 2 amino acids of formula (III):
• Xaa9Xaa10 (III)
• wherein Xaa9 is a positively charged amino acid and Xaa10 can be present or absent and, when present, Xaa10 is a non-polar amino acid.