Novel ergostenol glycoside derivative
AssigneeSt Pharm Co., Ltd.
InventorsHakwon KIM, Tae Hoon LEE, Hoongyu PARK, Hyunjeong OH
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Abstract
The present invention provides ergostenol glycoside derivatives, method for preventing, treating, or alleviating dermatitis using the same. The present invention also provides a method for preparing the ergostenol and glycoside derivatives thereof. The ergostenol and the glycoside derivatives thereof according to the present invention suppress the production of chemokines increasing according to the skin inflammation stimulation and inhibit the activity of transcriptional factors controlling the expression of various inflammation mediators in the prevention and treatment of dermatitis.
Claims13
A compound represented by Formula 1 or pharmaceutically acceptable salts thereof:
- wherein R is a monosaccharide or an amino sugar.
A composition comprising a compound represented by Formula 1 as an active ingredient:
- wherein R is selected from the group consisting of hydrogen, acetyl,
A method for preparing a compound represented by Formula 1 comprising a step:
- reacting ergosterol with a Pd/C catalyst in the presence of an alcohol solvent and a chlorinated organic solvent to prepare ergostenol,
- wherein R is selected from the group consisting of hydrogen, acetyl,
Dependencies are inferred from the claim text.