Antioxidant compounds and their use
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsXinyan Cui, Noah Snyder, Kasey Catt, James Eles
Life of this patent
Estimating the term…
Abstract
Disclosed herein are novel amine-functionalized porphyrin compounds, as wells as pharmaceutically acceptable salts or esters thereof. The disclosed compounds can be used to impart antioxidant, anti-inflammatory, anti-microbial, and/or cell-adhesion specificity to a surface or material in need thereof, such as a surface of an indwelling medical implant, or a marine surface.
Claims12
A method of reducing formation of a biofilm on a surface, reducing biofouling of a surface, and/or reducing corrosion of a metal surface, comprising coating the surface with an effective amount of:
- (i) A compound or salt or ester thereof, comprising a structure as set forth as one of:
- wherein:
- R1 independently comprises the structure:
- A is independently an optionally substituted N-heterocyclic aromatic ring;
- x is independently an integer from 0 to 6;
- a, if present, is independently 0 or 1
- R2 is independently lower aminoalkyl or lower aminoaryl;
- and
- R3, R4, R5, and R6, if present, are selected from one of (a)-(e):
- (a) ethyl, methyl,
- and methyl, respectively (Chlorophyll A, D);
- (b) ethyl,
- and methyl, respectively (Chlorophyll B);
- (c) ethyl, methyl,
- and methyl, respectively (Chlorophyll C1);
- (d)
- and methyl, respectively (Chlorophyll C2);
- (e) ethyl, methyl,
- respectively (Chlorophyll F);
- R7 and R8, if present, are selected from one of (f)-(h):
- (f)
- respectively (Heme A);
- (g)
- and methyl, respectively (Heme B);
- (h)
- and methyl, respectively, (Heme O);
- and
- M is a metal selected from the group consisting of manganese, iron, copper, cobalt, nickel, magnesium, and zinc, and optionally is not present;
- and/or
- (ii) a compound comprising a structure as set forth as Formula I:
- wherein:
- R1 independently comprises the structure:
- A is independently an optionally substituted N-heterocyclic aromatic ring;
- x is independently an integer from 0 to 6;
- R2 is independently lower aminoalkyl or lower aminoaryl;
- M is a metal selected from the group consisting of manganese, iron, copper, cobalt, nickel, magnesium, and zinc, and optionally is not present, and
- wherein the surface is not the surface of a neural implant.
Dependencies are inferred from the claim text.