Novel 4-(Aryl)-N-(3-Alkoxyfuro[2,3-b]pyrazin-2-yl)-Piperazine-1-Carboxamide Derivative and Antiproliferative Effect Thereof
AssigneeLsk Nrdo Co., Ltd.
InventorsYoung-Dae Gong, Soo-Youl Kim, Eun Sil Lee, Tae-Sung Koo, Nam-Sook Kang, Na Yeon
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Abstract
The present invention relates to a novel 4-(aryl)-N-(3-alkoxyfuro[2,3-b]pyrazin-2-yl)-piperazine-1-carboxamide derivative compound useful in the prevention or treatment of cancer; a preparation method thereof; and a pharmaceutical composition comprising the same. The novel 4-(aryl)-N-(3-alkoxyfuro[2,3-b]pyrazin-2-yl)-piperazine-1-carboxamide derivative compound of the present invention can effectively inhibit the growth of proliferating cells, and thus can be useful in the prevention or treatment of cancer.
Claims17
A compound represented by the following Formula 1 or a pharmaceutically acceptable salt thereof:
- wherein
- R1 is hydrogen, linear or branched C1-6 alkyl, or halogen;
- R2 is linear or branched C1-6 alkyl;
- and
- R3 to R7 each independently represent hydrogen, halogen, linear or branched C1-6 alkyl, linear or branched C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, (C1-6 alkyl)amino(C1-6 alkoxy), or di(C1-6 alkyl)amino(C1-6 alkoxy).
A method for preventing or treating cancer, comprising providing a subject with a compound:
- wherein
- R1 is hydrogen, linear or branched C1-6 alkyl, or halogen;
- R2 is linear or branched C1-6 alkyl;
- and
- R3 to R7 each independently represent hydrogen, halogen, linear or branched C1-6 alkyl, linear or branched C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, (C1-6 alkyl)amino(C1-6 alkoxy), or di(C1-6 alkyl)amino(C1-6 alkoxy), or the pharmaceutically acceptable salt thereof as an active ingredient.
Dependencies are inferred from the claim text.