US 2019/0337954 A1 · VIRAL REPLICATION INHIBITORS

wherein

moiety

is optionally substituted by one or more Z1 and

each dotted line represents an optional double bond whereby maximally 6 non-adjacent dotted lines can form a double bond;

each of X1, X2, X3, X5, X6, X7, and X8 is independently selected from CR3, N, NR4, O, and S;

each of X4 and X9 is independently selected from C, CH, and N;

X10 is selected from C, CH, and N;

whereby at least five of X1 to X10 are selected from CR3, C, and CH;

and at least one of X1 to X10 is a heteroatom;

p is 0, 1, or 2;

q is 0, 1, or 2;

cycle B is selected from aryl and heterocycle, wherein said aryl and heterocycle are unsubstituted;

R1 is selected from cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, heterocycle, arylalkyl, arylalkenyl, arylalkynyl, heterocycle-alkyl, heterocycle-alkenyl, heterocycle-alkynyl, arylheteroalkenyl, arylheteroalkynyl, heterocycle-hetero alkyl, heterocycle-heteroalkenyl, and heterocycle-heteroalkynyl;

and wherein said cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, heterocycle, arylalkyl, arylalkenyl, arylalkynyl, heterocycle-alkyl, heterocycle-alkenyl, heterocycle-alkynyl, arylheteroalkenyl, arylheteroalkynyl, heterocycle-heteroalkyl, heterocycle-heteroalkenyl, and heterocycle-heteroalkynyl, are optionally substituted with one, two, or three Z1b;

R2 is selected from hydrogen, —C(O)Z3, alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, and heteroalkynyl;

and wherein said alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, and heteroalkynyl, are optionally substituted with one, two, or three Z1c;

each R3 is independently selected from hydrogen and Z1;

each R4 is independently selected from hydrogen, hydroxyl, sulfhydryl, —S(═O)Z2, —S(═O)2Z3, —S(═O)2NZ4Z5, trifluoromethyl, —C(═O)Z3, —C(═O)OZ2, —C(═O)NZ4Z5, —C(═O)H, alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, heteroalkynyl, aryl, heterocycle, arylalkyl, arylalkenyl, arylalkynyl, arylheteroalkyl, arylheteroalkenyl, arylheteroalkynyl, heterocycle-alkyl, heterocycle-alkenyl, heterocycle-alkynyl, heterocycle-heteroalkyl, heterocycle-heteroalkenyl, and heterocycle-heteroalkynyl;

and wherein said alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, heteroalkynyl, aryl, heterocycle, arylalkyl, arylalkenyl, arylalkynyl, arylheteroalkyl, arylheteroalkenyl, arylheteroalkynyl, heterocycle-alkyl, heterocycle-alkenyl, heterocycle-alkynyl, heterocycle-heteroalkyl, heterocycle-heteroalkenyl, and heterocycle-heteroalkynyl are optionally substituted with one, two, or three substituents selected from alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, heteroalkynyl, hydroxyl, ═O, halogen, —SH, ═S, trifluoromethyl, —OCF3, cyano, nitro, —C(═O)OH, —C(O)Oalkyl, and —N(CH3)2, —NH2, —NH—C(═O)O—C1-4alkyl, —O-alkyl;

each Z1, Z1b, and Z1c is independently selected from the group consisting of halogen, hydroxyl, sulfhydryl, —OZ2, —O—C(═O)Z3, ═O, —SZ2, ═S, —S(═O)Z2, —S(═O)2Z3, —S(═O)2NZ4Z5, trifluoromethyl, trifluoromethoxy, nitro, —NZ4Z5, —NZ4S(═O)2Z2, —NZ4C(═O)Z2, —NZ4C(═O)—OZ2, —NZ4C(═O)NZ4Z5, cyano, —C(═O)Z3, —C(═O)OZ2, —C(═O)NZ4Z5, —C(═O)H, alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, heteroalkynyl, aryl, heterocycle, arylalkyl, arylalkenyl, arylalkynyl, arylheteroalkyl, arylheteroalkenyl, arylheteroalkynyl, heterocycle-alkyl, heterocycle-alkenyl, heterocycle-alkynyl, heterocycle-heteroalkyl, heterocycle-heteroalkenyl, and heterocycle-heteroalkynyl;

and wherein said alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, heteroalkynyl, aryl, heterocycle, arylalkyl, arylalkenyl, arylalkynyl, arylheteroalkyl, arylheteroalkenyl, arylheteroalkynyl, heterocycle-alkyl, heterocycle-alkenyl, heterocycle-alkynyl, heterocycle-heteroalkyl, heterocycle-heteroalkenyl, and heterocycle-heteroalkynyl, are optionally substituted with one, two, or three substituents selected from alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, heteroalkynyl, hydroxyl, ═O, halogen, —SH, ═S, trifluoromethyl, —OCF3, —O—C(O)Me, cyano, nitro, —C(O)OH, —C(O)Oalkyl, —NH2, —NHCH3;

—N(CH3)2, —NH—C(═O)O—C1-4alkyl, morpholinyl, —S(O)2C1-4alkyl, and —O-alkyl;

each Z2 is independently selected from alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, heteroalkynyl, aryl, heterocycle, arylalkyl, arylalkenyl, arylalkynyl, arylheteroalkyl, arylheteroalkenyl, arylheteroalkynyl, heterocycle-alkyl, heterocycle-alkenyl, heterocycle-alkynyl, heterocycle-heteroalkyl, heterocycle-heteroalkenyl, and heterocycle-heteroalkynyl;

wherein said alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, heteroalkynyl, aryl, heterocycle, arylalkyl, arylalkenyl, arylalkynyl, arylheteroalkyl, arylheteroalkenyl, arylheteroalkynyl, heterocycle-alkyl, heterocycle-alkenyl, heterocycle-alkynyl, heterocycle-heteroalkyl, heterocycle-heteroalkenyl, and heterocycle-heteroalkynyl, are optionally substituted with one, two, or three substituents selected from alkyl, alkenyl, alkynyl, hydroxyl, ═O, halogen, —SH, ═S, trifluoromethyl, difluoromethyl, —O-alkyl, —OCF3, —S(═O)2C1-4alkyl, cyano, nitro, —C(═O)OH, —C(═O)O—C1-4alkyl, —NH2, and —N(CH3)2, pyrrolidinyl, piperidinyl, and piperazinyl;

each Z3 is independently selected from hydroxyl, alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, heteroalkynyl, aryl, heterocycle, arylalkyl, arylalkenyl, arylalkynyl, arylheteroalkyl, arylheteroalkenyl, arylheteroalkynyl, heterocycle-alkyl, heterocycle-alkenyl, heterocycle-alkynyl, heterocycle-heteroalkyl, heterocycle-heteroalkenyl, and heterocycle-heteroalkynyl;

wherein said alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, heteroalkynyl, aryl, heterocycle, arylalkyl, arylalkenyl, arylalkynyl, arylheteroalkyl, arylheteroalkenyl, arylheteroalkynyl, heterocycle-alkyl, heterocycle-alkenyl, heterocycle-alkynyl, heterocycle-heteroalkyl, heterocycle-heteroalkenyl, and heterocycle-heteroalkynyl, are optionally substituted with one, two, or three substituents selected from alkyl, alkenyl, alkynyl, hydroxyl, ═O, halogen, —SH, ═S, trifluoromethyl, —O-alkyl, —OCF3, cyano, nitro, —C(═O)OH, —NH2, and —N(CH3)2;

each Z4 and Z5 is independently selected from hydrogen, alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, heteroalkynyl, aryl, cycloalkyl, heterocycle, arylalkyl, arylalkenyl, arylalkynyl, arylheteroalkyl, arylheteroalkenyl, arylheteroalkynyl, heterocycle-alkyl, heterocycle-alkenyl, heterocycle-alkynyl, heterocycle-heteroalkyl, heterocycle-heteroalkenyl, and heterocycle-heteroalkynyl;

wherein said alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, heteroalkynyl, aryl, heterocycle, arylalkyl, arylalkenyl, arylalkynyl, arylheteroalkyl, arylheteroalkenyl, arylheteroalkynyl, heterocycle-alkyl, heterocycle-alkenyl, heterocycle-alkynyl, heterocycle-heteroalkyl, heterocycle-heteroalkenyl, and heterocycle-heteroalkynyl, are optionally substituted with one, two, or three substituents selected from alkyl, alkenyl, alkynyl, hydroxyl, ═O, halogen, —SH, ═S, trifluoromethyl, —O-alkyl, —OCF3, cyano, nitro, or —NH2;

and wherein Z4 and Z5 can be taken together in order to form a (5-, 6-, or 7-membered) heterocycle which is optionally substituted with alkyl, alkenyl, alkynyl, hydroxyl, halogen, —SH, trifluoromethyl, —O-alkyl, —OCF3, cyano, nitro, —C(═O)OH, or —NH2;

or a stereo-isomer thereof, or a tautomer thereof, or a pharmaceutically acceptable salt thereof, or a prodrug thereof,

wherein the term “alkyl” as used herein means a normal, secondary, or tertiary, linear or cyclic (or a combination of linear and cyclic), branched or straight hydrocarbon with no site of unsaturation

with the proviso that compound per se of formula (B) is not

N-(5-(2-(7-ethyl-1H-indol-3-yl)-2-oxo-1-phenylethylamino)-2-methoxyphenyl)-methanesulfonamide (CAS nr. 1294288-37-1);

3-(2-(1H-indol-3-yl)-2-oxo-1-phenylethylamino)benzenesulfonamide (CAS nr. 1211427-21-2);

2-(3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-ylamino)-1-(1H-indol-3-yl)-2-phenylethanone (CAS nr. 1090733-87-1);

1-(1H-indol-3-yl)-2-phenyl-2-(pyridin-3-ylmethylamino)ethanone (CAS nr. 875860-58-5);

2-(benzo[d][1,3]dioxol-5-ylmethylamino)-1-(1H-indol-3-yl)-2-phenylethanone (CAS nr. 920816-95-1);

1-(7-ethyl-1H-indol-3-yl)-2-[(1-methyl-1H-pyrazol-3-yl)amino]-2-phenyl-ethanone (CAS nr. 1296377-78-0);

N-[4-[[2-(1H-indol-3-yl)-2-oxo-1-phenylethyl]amino]phenyl]-2-methyl-propanamide (CAS nr. 1294813-77-6);

N-[4-[[2-(7-ethyl-1H-indol-3-yl)-2-oxo-1-phenylethyl]amino]-2-methoxyphenyl]-acetamide (CAS nr. 1287503-18-7);

1-(7-ethyl-1H-indol-3-yl)-2-phenyl-2-[(3,4,5-trimethoxyphenyl)amino]-ethanone (CAS nr. 1287040-60-1);

2-[(1-acetyl-2,3-dihydro-1H-indol-5-yl)amino]-1-(7-ethyl-1H-indol-3-yl)-2-phenyl-ethanone (CAS nr. 1286579-37-0);

3,4-dihydro-6-[[2-(1H-indol-3-yl)-2-oxo-1-phenylethyl]amino]-2(1H)-quinolinone (CAS nr. 1277962-26-1);

1-(1H-indol-3-yl)-2-phenyl-2-(m-tolylamino)ethanone (CAS nr. 1252467-88-1);

2-(4-ethoxy-3-(hydroxymethyl)phenylamino)-1-(1H-indol-3-yl)-2-phenylethanone (CAS nr. 1241127-58-1);

2-[(1-acetyl-4-piperidinyl)amino]-1-(1H-indol-3-yl)-2-phenyl-ethanone (CAS nr. 1210169-39-3);

1-(1H-indol-3-yl)-2-[(6-methoxy-3-pyridinyl)amino]-2-phenyl-ethanone (CAS nr. 1181884-55-8);

1-(1H-indol-3-yl)-2-[(1-methyl-1H-pyrazol-3-yl)amino]-2-phenyl-ethanone (CAS nr. 1134766-19-0);

3-[[2-(1H-indol-3-yl)-2-oxo-1-phenylethyl]amino]-benzamide (CAS nr. 1062257-51-5);

N-[4-[[2-(1H-indol-3-yl)-2-oxo-1-phenylethyl]amino]phenyl]-2,2-dimethyl-propanamide (CAS nr. 1062132-16-4);

N-[3-[[2-(1H-indol-3-yl)-2-oxo-1-phenylethyl]amino]phenyl]-acetamide (CAS nr. 1030735-63-7);

2-[(3,5-dimethoxyphenyl)amino]-1-(1H-indol-3-yl)-2-phenyl-ethanone (CAS nr. 1030232-46-2);

1-(1H-indol-3-yl)-2-phenyl-2-(phenylamino)-ethanone (CAS nr. 1030214-83-5);

1-(1H-indol-3-yl)-2-[[6-(4-morpholinyl)-3-pyridinyl]amino]-2-phenyl-ethanone (CAS nr. 1030212-41-9);

2-(3-(difluoromethoxy)-4-methoxyphenylamino)-1-(1H-indol-3-yl)-2-phenylethanone (CAS nr. 1015662-06-2);

1-(1H-indol-3-yl)-2-phenyl-2-[(3,4,5-trimethoxyphenyl)amino]-ethanone (CAS nr. 1014535-82-0);

2-[(4-fluorophenyl)amino]-1-(1H-indol-3-yl)-2-phenyl-ethanone (CAS nr. 1014493-63-0);

2-[(4-ethoxy-3-methoxyphenyl)amino]-1-(1H-indol-3-yl)-2-phenyl-ethanone (CAS nr. 1014422-80-0);

N-[4-[[2-(1H-indol-3-yl)-2-oxo-1-phenylethyl]amino]phenyl]-acetamide (CAS nr. 1013712-88-3);

1-(7-ethyl-1H-indol-3-yl)-2-[[3-(hydroxymethyl)phenyl]amino]-2-phenyl-ethanone (CAS nr. 1012956-97-6);

N-[2-chloro-4-[[2-(1H-indol-3-yl)-2-oxo-1-phenylethyl]amino]phenyl]-acetamide (CAS nr. 1011120-58-3);

1-[4-[[2-(1H-indol-3-yl)-2-oxo-1-phenylethyl]amino]-2-methoxyphenyl]-2-pyrrolidinone (CAS nr. 1011119-79-1);

N-cyclopropyl-4-[[2-(1H-indol-3-yl)-2-oxo-1-phenylethyl]amino]-benzamide (CAS nr. 1011113-94-2);

2-[(1-acetyl-2,3-dihydro-1H-indol-5-yl)amino]-1-(1H-indol-3-yl)-2-phenyl-ethanone (CAS nr. 949443-90-7);

1-(1H-indol-3-yl)-2-phenyl-2-[(1-propyl-4-piperidinyl)amino]-ethanone (CAS nr. 941047-24-1);

2-(cyclopentylamino)-1-(1H-indol-3-yl)-2-phenyl-ethanone (CAS nr. 931079-25-3);

1-(1H-indol-3-yl)-2-[(4-methylphenyl)amino]-2-phenyl-ethanone (CAS nr. 931016-79-4);

2-(cyclopropylamino)-1-(1H-indol-3-yl)-2-phenyl-ethanone (CAS nr. 931000-99-6);

1-[4-[[2-(1H-indol-3-yl)-2-oxo-1-phenylethyl]amino]phenyl]-2-pyrrolidinone (CAS nr. 924713-83-7);

2-[(3,4-dihydro-2H-1-benzothiopyran-4-yl)amino]-1-(1H-indol-3-yl)-2-phenyl-ethanone (CAS nr. 924713-60-0);

2-[(3,4-dimethoxyphenyl)amino]-1-(1H-indol-3-yl)-2-phenyl-ethanone (CAS nr. 924712-67-4);

1-[3-[[2-(1H-indol-3-yl)-2-oxo-1-phenylethyl]amino]phenyl]-2-pyrrolidinone (CAS nr. 920952-63-2);

2-ethoxy-5-[[2-(1H-indol-3-yl)-2-oxo-1-phenylethyl]amino]-N,N-dimethyl-benzenesulfonamide (CAS nr. 920883-17-6);

6-[[2-(1H-indol-3-yl)-2-oxo-1-phenylethyl]amino]-2-methyl-2H-1,4-benzoxazin-3 (4H)-one (CAS nr. 920834-07-7);

2-[(3,4-dihydro-2H-1-benzopyran-4-yl)amino]-1-(1H-indol-3-yl)-2-phenyl-ethanone (CAS nr. 920819-87-0);

3-[[2-(1H-indol-3-yl)-2-oxo-1-phenylethyl]amino]-N-methyl-benzamide (CAS nr. 920672-79-3);

4-[[2-(1H-indol-3-yl)-2-oxo-1-phenylethyl]amino]-benzeneacetonitrile (CAS nr. 920669-36-9);

1-(1H-indol-3-yl)-2-[(4-methoxyphenyl)amino]-2-phenyl-ethanone (CAS nr. 920601-77-0);

1-(1H-indol-3-yl)-2-phenyl-2-(1,1-dioxotetrahydrothiophen-3-ylamino)ethanone (CAS nr. 878619-92-2);

N-cyclopropyl-3-[[2-(1H-indol-3-yl)-2-oxo-1-phenylethyl]amino]-benzamide (CAS nr. 878577-28-7);

2-[[3-(hydroxymethyl)phenyl]amino]-1-(1H-indol-3-yl)-2-phenyl-ethanone (CAS nr. 875166-36-2);

2-[(2,3-dihydro-1,4-benzodioxin-6-yl)amino]-1-(1H-indol-3-yl)-2-phenyl-ethanone (CAS nr. 874669-99-5);

1-(1H-indol-3-yl)-2-(methyl((tetrahydrofuran-2-yl)methyl)amino)-2-phenylethanone;

N-(4-(2-(1H-indol-3-yl)-2-oxo-1-phenylethylamino)phenyl)isobutyramide;

2-((benzo[d][1,3]dioxol-5-ylmethyl)(methyl)amino)-1-(1H-indol-3-yl)-2-phenylethanone;

3-(3-(2-(7-ethyl-1H-indol-3-yl)-2-oxo-1-phenylethylamino)propyl)-1,3-diazaspiro[4.4]nonane-2,4-dione;

1-(7-ethyl-1H-indol-3-yl)-2-((2-methoxypyridin-3-yl)methylamino)-2-phenylethanone;

3-(3-(2-(1H-indol-3-yl)-2-oxo-1-phenylethylamino)propyl)-1,3-diazaspiro[4.4]nonane-2,4-dione;

1-(1H-indol-3-yl)-2-(methyl(2,3,4-trimethoxybenzyl)amino)-2-phenylethanone;

1-(1H-indol-3-yl)-2-(morpholino(phenyl)methylamino)-2-phenylethanone;

2-(4-(dimethylamino)benzylamino)-1-(1H-indol-3-yl)-2-phenylethanone;

2-(2-(furan-2-yl)ethylamino)-1-(1H-indol-3-yl)-2-phenylethanone;

3-(2-(1H-indol-3-yl)-2-oxo-1-phenylethylamino)-1-(pyrrolidin-1-yl)propan-1-one;

2-(1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)ethylamino)-1-(1H-indol-3-yl)-2-phenylethanone;

2-((2,3-dimethoxybenzyl)(methyl)amino)-1-(1H-indol-3-yl)-2-phenylethanone;

2-((3,4-dimethoxybenzyl)(methyl)amino)-1-(1H-indol-3-yl)-2-phenylethanone;

1-(1H-indol-3-yl)-2-phenyl-2-(2-(thiophen-2-yl)ethylamino)ethanone;

2-(1-(furan-2-yl)ethylamino)-1-(1H-indol-3-yl)-2-phenylethanone;

1-(1H-indol-3-yl)-2-(2-methoxybenzylamino)-2-phenylethanone;

1-(1H-indol-3-yl)-2-(methyl(thiophen-2-ylmethyl)amino)-2-phenylethanone;

1-(1H-indol-3-yl)-2-phenyl-2-((tetrahydrofuran-2-yl)methylamino)ethanone;

1-(1H-indol-3-yl)-2-(3-methoxybenzylamino)-2-phenylethanone;

2-(2-(dimethylamino)-1-phenylethylamino)-1-(1H-indol-3-yl)-2-phenylethanone;

1-(1H-indol-3-yl)-2-(methyl(thiophen-3-ylmethyl)amino)-2-phenylethanone;

1-(1H-indol-3-yl)-2-phenyl-2-(1-(thiophen-2-yl)ethylamino)ethanone;

2-(3,4-dimethoxyphenethylamino)-1-(1H-indol-3-yl)-2-phenylethanone;

1-(1H-indol-3-yl)-2-(1-(2-methoxyphenyl)ethylamino)-2-phenylethanone;

1-(1H-indol-3-yl)-2-(4-methoxybenzylamino)-2-phenylethanone;

1-(1H-indol-3-yl)-2-phenyl-2-(pyridin-2-ylmethylamino)ethanone;

2-(benzylamino)-1-(1H-indol-3-yl)-2-phenylethanone;

2-(furan-2-ylmethylamino)-1-(1H-indol-3-yl)-2-phenylethanone;

2-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methylamino)-1-(1H-indol-3-yl)-2-phenylethanone;

1-(1H-indol-3-yl)-2-phenyl-2-(thiophen-2-ylmethylamino)ethanone;

N-[5-[[2-(7-ethyl-1H-indol-3-yl)-2-oxo-1-phenyl-ethyl]amino]-2-methylphenyl]methanesulfonamide;

1-(1H-indol-3-yl)-2-phenyl-2-[4-(tetrahydrofuran-2-ylmethoxy)anilino]ethanone;

1-[[4-[[2-(7-ethyl-1H-indol-3-yl)-2-oxo-1-phenyl-ethyl]amino]phenyl]methyl]piperidin-2-one;

1-(1H-indol-3-yl)-2-phenyl-2-[4-(2-pyridylmethoxy)anilino]ethanone;

N-[5-[[2-(1H-indol-3-yl)-2-oxo-1-phenyl-ethyl]amino]-2-methoxy-phenyl]methanesulfonamide;

2-[4-[[2-(1H-indol-3-yl)-2-oxo-1-phenyl-ethyl]amino]phenyl]-N,N-dimethyl-acetamide;

4-[[2-(7-ethyl-1H-indol-3-yl)-2-oxo-1-phenyl-ethyl]amino]-1,5-dimethyl-2-phenyl-pyrazol-3-one;

4-[[2-(1H-indol-3-yl)-2-oxo-1-phenyl-ethyl]amino]-1,5-dimethyl-2-phenyl-pyrazol-3-one;

N-[4-[[2-(7-ethyl-1H-indol-3-yl)-2-oxo-1-phenyl-ethyl]amino]phenyl]-2-morpholino-acetamide;

N-[4-[[2-(1H-indol-3-yl)-2-oxo-1-phenyl-ethyl]amino]phenyl]cyclopropanecarboxamide;

3-[[(1 S)-2-(1H-indol-3-yl)-2-oxo-1-phenyl-ethyl]amino]-N-methylbenzamide;

(2S)-2-(1,3-benzodioxol-5-ylamino)-1-(1H-indol-3-yl)-2-phenylethanone;

N-[4-[[(1 S)-2-(1H-indol-3-yl)-2-oxo-1-phenyl-ethyl]amino]phenyl]acetamide;

(2S)-2-(2,3-dihydro-1,4-benzodioxin-6-ylamino)-1-(1H-indol-3-yl)-2-phenylethanone;

(2S)-2-anilino-1-(1H-indol-3-yl)-2-phenylethanone;

(2S)-1-(1H-indol-3-yl)-2-(3-methylanilino)-2-phenylethanone;

(2S)-1-(1H-indol-3-yl)-2-(3-methoxyanilino)-2-phenylethanone;

(2S)-1-(1H-indol-3-yl)-2-(4-methylanilino)-2-phenylethanone;

(2S)-1-(1H-indol-3-yl)-2-(4-methoxyanilino)-2-phenylethanone;

Methyl 4-[[(1S)-2-(1H-indol-3-yl)-2-oxo-1-phenylethyl]amino]benzoate;

(2S)-1-(1H-indol-3-yl)-2-phenyl-2-(3,4,5-trimethoxyanilino)ethanone;

N-[3-[[(1 S)-2-(1H-indol-3-yl)-2-oxo-1-phenylethyl]amino]phenyl]acetamide;

1-[4-[[(1 S)-2-(1H-indol-3-yl)-2-oxo-1-phenylethyl]amino]phenyl]pyrrolidin-2-one;

(2S)-2-(4-ethoxy-3-methoxyanilino)-1-(1H-indol-3-yl)-2-phenylethanone;

1-[3-[[(1 S)-2-(1H-indol-3-yl)-2-oxo-1-phenylethyl]amino]phenyl]pyrrolidin-2-one;

2-[4-[[(1 S)-2-(1H-indol-3-yl)-2-oxo-1-phenylethyl]amino]phenyl]acetonitrile;

(2S)-2-(4-fluoroanilino)-1-(1H-indol-3-yl)-2-phenylethanone;

N-cyclopropyl-3-[[(1 S)-2-(1H-indol-3-yl)-2-oxo-1-phenylethyl]amino]benzamide;

(2R)-2-[(1-acetyl-2,3-dihydroindol-5-yl)amino]-1-(1H-indol-3-yl)-2-phenylethanone;

(2S)-1-(7-ethyl-1H-indol-3-yl)-2-phenyl-2-(3,4,5-trimethoxyanilino)ethanone;

(2S)-2-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylamino)-1-(1H-indol-3-yl)-2-phenylethanone;

N-[4-[[(1R)-2-(7-ethyl-1H-indol-3-yl)-2-oxo-1-phenylethyl]amino]phenyl]ethanesulfonamide;

(2R)—N-[3-[[(1R)-2-(7-ethyl-1H-indol-3-yl)-2-oxo-1-phenylethyl]amino]phenyl]-2-methoxypropanamide;

or

5-[[(1R)-2-(7-ethyl-1H-indol-3-yl)-2-oxo-1-phenylethyl]amino]-3H-1,3-benzoxazol-2-one

N-(5[(2-(1H-indol-3-yl)-2-oxo-1-phenylethyl]amino]-1-methoxyphenyl)-methansufonamide (CAS nr. 1295460-37-5).

Viral replication inhibitors

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Viral replication inhibitors

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Abstract

Claims40