Triazolopyridine compounds and methods of use thereof

A compound of formula (I):

• or a stereoisomer, tautomer, solvate, prodrug or salt thereof, wherein:
• R1a is hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, phenyl, or 3-11 membered heterocyclyl and R1a is optionally substituted by R9;
• R1b and R1c are each independently hydrogen, C1-C6 alkyl, or C3-C8 cycloalkyl;
• R2 is a 3-11 membered heterocyclyl containing at least 1 nitrogen, selected from groups (a)-(e) and (h)-(j);
• a C5-C8 cycloalkenyl ring (f);
• a —O—(CRxRy)q—Ar2 group (g);
• or a Ar1—O—(CRxRy)q—Ar2 group (k), where each Rx and Ry are independently hydrogen or C1-C6 alkyl, each q is independently 0 to 3, Ar1 is 1,4-phenylene and Ar2 is optionally substituted C6-C10 aryl or optionally substituted 5-11 membered heteroaryl:
• wherein the wavy line represents the point of attachment of R2 in formula (I);
• R3, R4 and R5 are each independently selected from the group consisting of hydrogen, CH3, CH2CH3, OCH3, CF3, F and Cl;
• R6 and R7 are independently selected from the group consisting of hydrogen, halogen, OH, CN, phenyl, C1-C6 alkyl, (C0-C6 alkylene)C3-C8 cycloalkyl, (C0-C6 alkylene)3-11 membered heterocyclyl, (C0-C6 alkylene)C(O)NRaRb, (C0-C6 alkylene)NRaC(O)(C1-C6 alkyl), (C0-C6 alkylene)NRaC(O)(phenyl), (C0-C6 alkylene)C(O)R8a, (C0-C6 alkylene)C(O)OR8a, C1-C6 alkoxy, —O—(C3-C6 cycloalkyl), —O—(C0-C6 alkylene)C(O)NRaRb, —C═N—O—(C1-C6 alkyl), —O—(C1-C6 alkyl)3-11 membered heterocyclyl, (C0-C6 alkylene)NRaSO2(C1-C6 alkyl), (C0-C6 alkylene)NRaSO2(phenyl), and —O-(3-11 membered heterocyclyl);
• wherein said alkyl, alkylene, alkoxy, cycloalkyl, phenyl and heterocyclyl are each independently optionally substituted,
• or R6 and R7 together form an optionally substituted phenyl or optionally substituted 3-11 membered heterocyclyl;
• R8 is H, C1-C6 alkyl, (C0-C6 alkylene)phenyl, (C0-C6 alkylene)C3-C8 cycloalkyl, (C0-C6 alkylene)3-11 membered heterocyclyl, C(O)NRaRb, SO2NRaRb, (C1-C6 alkylene)C(O)OR8a or C(O)R8a, wherein said alkyl, alkylene, heterocyclyl and phenyl are each independently optionally substituted;
• R8a is H, NRaRb, C1-C6 alkyl, (C0-C6 alkylene)C3-C8 cycloalkyl, (C0-C6 alkylene)phenyl, or (C0-C6 alkylene)3-11 membered heterocyclyl, wherein said alkyl, alkylene, cycloalkyl, phenyl and heterocyclyl are each independently optionally substituted;
• R8aa is H, C1-C6 alkyl optionally substituted by OH, or C(O)NRaRb;
• or
• or R8 and R8aa together form an optionally substituted 3-11 membered heterocyclyl;
• R9, independently at each occurrence, is OH, halogen, CN, C1-C6 alkyl, C3-C8 cycloalkyl, phenyl, 3-11 membered heterocyclyl, 5-11 membered heteroaryl, —C(O)NRaRb, —NRaRb, (C1-C6 alkylene)C3-C8 cycloalkyl, (C1-C6 alkylene)phenyl, (C1-C6 alkylene)3-11 membered heterocyclyl, (C1-C6 alkylene)5-11 membered heteroaryl, (C1-C6 alkylene)C(O)NRaRb, (C1-C6 alkylene)NRaRb, or C(O)(C1-C6 alkyl), wherein said alkyl, alkylene, cycloalkyl, phenyl, heterocyclyl and heteroaryl are each independently optionally substituted;
• Ra and Rb, independently at each occurrence, are selected from the group consisting of hydrogen, C1-C6 alkyl optionally substituted by halogen or CN, (C0-C6 alkylene)C3-C8 cycloalkyl, or (C0-C6 alkylene)phenyl, and wherein one or more alkylene units of any alkyl group is independently optionally substituted by —O—, or alternatively Ra and Rb may be joined together with the nitrogen atom to which they are attached to form an optionally substituted 3-11 membered heterocyclyl;
• and
• m1, m2, m3 and m4 are each independently 0, 1 or 2.