Jak inhibitors containing a 4-membered heterocyclic amide
AssigneeTheravance Biopharma R&D IP, LLC
InventorsPaul R. FATHEREE, Gary E.L. Brandt, Cameron Smith, Steven D.E. Sullivan, Lori Jean Van Orden, Melanie A. Kleinschek, Glenn D. Crater
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Abstract
The invention provides compounds of formula (I): which contain a 4-membered heterocyclic amide, where the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat respiratory diseases, and processes and intermediates useful for preparing such compounds.
Claims11
1-12. (canceled)
A method of treating a respiratory disease in a mammal, the method comprising administering to the mammal a pharmaceutical composition comprising a compound of the formula:
- or a pharmaceutically-acceptable salt thereof, and a pharmaceutically-acceptable carrier.
A method of treating lung transplant rejection in a mammal, the method comprising administering to the mammal a pharmaceutical composition comprising a compound of the formula:
- or a pharmaceutically-acceptable salt thereof, and a pharmaceutically-acceptable carrier.
Dependencies are inferred from the claim text.