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US 2019/0337943 A1Published application
Synthesis of a compound that modulates kinases
AssigneesPlexxikon Inc., Daiichi Sankyo Company, Limited
InventorsPrabha N. Ibrahim, Masayoshi Jin, Shinji Matsuura
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Abstract
The present disclosure provides processes for the preparation of a compound of formula I: or a salt thereof, active on the receptor protein kinases c-Kit and/or c-Fms and/or Flt3. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.
Claims4
A crystalline form of a compound of formula II:
- prepared by a process comprising:
- (1) adding the compound of formula II to from about 0.4% v/v wet methyl tert-butyl ether to about 1.5% v/v wet methyl tert-butyl ether to provide a reaction mixture;
- (2) refluxing the reaction mixture;
- (3) cooling the reaction mixture to about room temperature;
- and
- (4) isolating the crystalline form of the compound of formula II from the reaction mixture.
3 more elements
Dependencies are inferred from the claim text.