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OwnerMichael Einziger, Ann Marie Simpsoninventors
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The present invention relates to compounds, compositions, and methods for modulating skin pigmentation and treating or preventing UV-induced skin damage, erythema, aging of the skin, sunburn, and hyperpigmentation in a subject. The compounds, compositions, and methods of the present invention generally involve Malassezia-derived compounds, including malassezin and indirubin, and/or chemical analogs thereof. Other applications of the compounds and compositions disclosed herein include, but are not limited to, improving hyperpigmentation caused by a hyperpigmentation disorder, inducing melanocyte apoptosis, and modulating aylhydrocarbon receptor (AhR) activity, melanogenesis, melanin production, melanosome biogenesis, melanosome transfer, melanocyte activity, and melanin concentration.
A compound for brightening skin, the compound having a structure of the following formula:
A compound for inducing melanocyte apoptosis, the compound having a structure of the following formula:
A compound for modulating arylhydrocarbon receptor (AhR) activity, the compound having a structure of the following formula:
A compound for modulating melanogenesis, the compound having a structure of the following formula:
A compound for modulating melanin concentration, the compound having a structure of the following formula:
A composition comprising a compound, the compound having a structure of the following formula:
A method for brightening skin in a subject, the method comprising contacting the subject with a compound, the compound having the structure of the following formula:
A method for inducing melanocyte apoptosis in a subject, the method comprising contacting the subject with a compound, the compound having the structure of the following formula:
A method for modulating arylhydrocarbon receptor (AhR) activity in a subject, the method comprising contacting the subject with a compound, the compound having the structure of the following formula:
A method for modulating melanogenesis in a subject, the method comprising contacting the subject with a compound, the compound having the structure of the following formula:
A method for modulating melanin concentration in a subject, the method comprising contacting the subject with a compound, the compound having the structure of the following formula:
Dependencies are inferred from the claim text.