Bicyclic aza compounds as muscarinic m1 receptor and/or m4 receptor
AssigneeHeptares Therapeutics Limited
InventorsGiles Albert Brown, Julie Elaine Cansfield, Miles Stuart Congreve, Michael Alistair O'Brien, Mark Pickworth, Mark David Rackham, Benjamin Gerald Tehan, Barry John Teobald
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Abstract
This invention relates to compounds that are agonists of the muscarinic M1 receptor and/or M4 receptor and which are useful in the treatment of muscarinic M1/M4 receptor mediated diseases. Also provided are pharmaceutical compositions containing the compounds and the therapeutic uses of the compounds. Compounds include those according to formula 1, or a salt thereof, wherein Q, R1, R2, R3 and R4 are as defined herein.
Claims21
1-26. (canceled)
A method of treating a cognitive disorder or psychotic disorder or of treating or lessening the severity of acute, chronic, neuropathic or inflammatory pain, comprising administering to a subject in need thereof an effective amount of a compound of the formula (1b):
- or a salt thereof, wherein
- Q is an optionally substituted five or six or seven membered heterocyclic ring containing 1, 2, 3 or 4 heteroatom ring members selected from N, O and S;
- R3 is selected from hydrogen;
- fluorine;
- cyano;
- hydroxy;
- amino;
- and a C1-9 non-aromatic hydrocarbon group which is optionally substituted with one to six fluorine atoms and wherein one, two or three, but not all, carbon atoms of the hydrocarbon group may optionally be replaced by a heteroatom selected from O, N and S and oxidized forms thereof;
- R4 is a hydrogen or a C1-6 non-aromatic hydrocarbon group which is optionally substituted with one to six fluorine atoms and wherein one or two, but not all, carbon atoms of the hydrocarbon group may optionally be replaced by a heteroatom selected from O, N and S and oxidised forms thereof;
- and the dotted line indicates an optional second carbon-carbon bond, provided that when a second carbon-carbon bond is present, then R3 is absent.
The method according to claim 40, wherein R3 is hydrogen.
Dependencies are inferred from the claim text.