Substituted hydantoin and thiohydantoin derivatives as androgen receptor antagonists

A compound of Formula (I)

• wherein
• Z is S;
• R1 is selected from the group consisting of chloro, methyl, methoxy, difluoromethyl, and trifluoromethyl;
• R2a and R2b is an unsubstituted or substituted C3-C10heterocyclyl pyrrolidinyl;
• wherein said substituted C3-C10heterocyclyl is optionally independently substituted with a C1-3alkyl or cyclopropyl substituent;
• X is C;
• Y is C;
• G is selected from the group consisting of g1
• wherein R3 is selected from the group consisting of hydrogen;
• C1-6alkyl optionally independently substituted with a substituent selected from hydroxy, methoxy, cyano, or fluoro;
• C3-6cycloalkyl optionally independently substituted with a substituent selected from hydroxy or fluoro;
• and —C(O)OR4, wherein R4 is C1-6alkyl or —CH2(C6-10aryl) wherein C6-10aryl is optionally substituted with a methoxy substituent;
• such that a substituent on C1-6alkyl or C3-6cycloalkyl is attached at a carbon atom other than the carbon atom directly attached to the G-nitrogen atom;
• wherein any nitrogen-containing heterocyclic substituent of G is optionally substituted with an oxido substituent to form an N-oxide;
• or an enantiomer, diastereomer, or pharmaceutically acceptable salt form thereof.