Rip1 inhibitory compounds and methods for making and using the same

A compound, having a formula

• or a pharmaceutically acceptable salt thereof, wherein:
• ring B is 5-membered or 6-membered heteroaryl;
• L is a heteroatom or Ra, provided that Ra is not H or D;
• Z is C1-10aliphatic (such as C1-10alkyl, C2-10alkenyl, C2-10alkynyl, or C3-6cycloalkyl);
• or
• R1 is a halogen, —C≡CH, or a -linker-R6 group, wherein the linker is Ra, provided that Ra is not H or D, and R6 is Rb, —C(Rf)3, or —C(Rf)═C(Rf)2;
• R2 and R3 independently are Ra;
• R4 and R5 independently are Re;
• Ra is independently for each occurrence H, D, C1-10aliphatic, C1-10haloaliphatic, C5-10aromatic, or C3-6heterocyclic;
• Rb is independently for each occurrence —OH, —SH, —ORc, —SRc, —NRdRd, —Si(Ra)3, —C(O)OH, —C(O)ORc, or —C(O)NRdRd;
• Rc is independently for each occurrence C1-10alkyl, C2-10alkenyl, C2-10alkynyl, C3-6cycloalkyl;
• Rd is independently for each occurrence H;
• C1-6alkyl;
• C3-6cycloalkyl;
• C3-6heterocyclic;
• C5-10aryl;
• C5-10heteroaryl;
• or two Rd groups together with the nitrogen bound thereto provide a C3-9heterocyclic, or a C5-10heteroaryl;
• Re is independently for each occurrence halogen, C1-6alkyl, C2-10alkenyl, C2-10alkynyl, C1-6haloalkyl, C3-6cycloalkyl, C5-10heteroaryl, or —ORa;
• Rf is independently for each occurrence Ra, Rb, or Re, or two Rf groups together with the carbon atom bound thereto provide a C3-6cycloalkyl group or a C3-10heterocyclic;
• m is 1 to 4;
• n is 0, 1 or 2;
• and
• p is 0, 1, 2, 3, 4, or 5.