Novel tetrahydronaphthyl urea derivative

A compound or an optical isomer thereof, a pharmaceutically acceptable salt thereof, or a solvate thereof, the compound represented by the following formula (I):

• where p represents an integer of 0, 1, 2, 3, or 4;
• R1 are each independently a hydrogen atom, a halogen atom, a cyano group, a C1-6 alkyl group, a halogenated C1-6 alkyl group, a hydroxy C1-6 alkyl group, a cyanated C1-6 alkyl group, a C1-6 alkoxy group, a halogenated C1-6 alkoxy group, a C1-6 alkoxy C1-6 alkyl group, a mono-/di-C2-7 alkahoyl amino group, a —C(═O)NH2 group, or a C1-6 alkoxy carbonyl group;
• R2a and R2b are each independently a hydrogen atom, a hydroxyl group, a halogen atom, a C1-6 alkyl group, a halogenated C1-6 alkyl group, a C1-6 alkoxy C1-6 alkyl group, a hydroxy C1-6 alkyl group, a cyanated C1-6 alkyl group, a C1-6 alkoxy group, a halogenated C1-6 alkoxy group, or a R4cR4dN—C1-6 alkyl group (the R4c and R4d are each independently a hydrogen atom, a C1-6 alkyl group, a hydroxy C1-6 alkyl group, or a halogenated C1-6 alkyl group);
• moreover, R2a and R2b are capable of bonding to each other to form a ring arbitrarily selected from the following partial structural formula (PS-1> to formula (PS-5):
• where Re in the partial structural formula (PS-5) is a hydrogen atom, a C1-6 alkyl group, a halogenated C1-6 alkyl group, a C3-8 cycloalkyl group, a halogenated C3-8 cycloalkyl group, a C1-6 alkoxy C1-6 alkyl group, a halogenated C1-6 alkoxy C1-6 alkyl group, a hydroxy C1-6 alkyl group, a hydroxy halogenated C1-6 alkyl group, or a cyanated C1-6 alkyl group;
• the ring A is the following partial structural formula (SS-1) to formula (SS-5):
• where R3 in the partial structural formula (SS-1) to formula (SS-5) is a hydrogen atom, a halogen atom, a C1-6 alkyl group, a C3-8 cycloalkyl group, a halogenated C1-6 alkyl group, a hydroxy C1-6 alkyl group, a C6-10 aryl group, a 5- or 6-membered heteroaryl group, or a non-aromatic heterocyclic group (the C6-10 aryl group, the 5- or 6-membered heteroaryl group, and the non-aromatic heterocyclic group may each have 1 to 3 substituent groups arbitrarily selected from a halogen atom and a C1-6 alkyl group);
• R4a is a hydrogen atom, a halogen atom, a cyano group, a C1-6 alkyl group, a halogenated C1-6 alkyl group, a hydroxy C1-6 alkyl group, a C1-6 alkoxy group, a hydroxy C1-6 alkoxy group, a halogenated C1-6 alkoxy group, a C1-6 alkoxy C1-6 alkyl group, a C1-6 alkoxy C1-6 alkoxy group, a C1-6 alkoxy carbonyl group, a —NR4cR4d group, a —CONR4cR4d group, a R4cR4dN—C1-6 alkoxy group (the R4c and R4d are each independently a hydrogen atom, a C1-6 alkyl group, a hydroxy C1-6 alkyl group, and a halogenated C1-6 alkyl group), a —C(═O)NH2 group, a halogenated mono-/di-C3-7 alkanoyl amino group, or a C1-6 alkylthio group;
• and
• R4b is a group arbitrarily selected from a hydrogen atom, a halogen atom, a hydroxyl group, a cyano group, a C1-6 alkyl group, a halogenated C1-6 alkyl group, a hydroxy halogenated C1-6 alkyl group, a hydroxy C1-6 alkyl group, a C1-6 alkoxy group, a hydroxy C1-6 alkoxy group, a halogenated C1-6 alkoxy group, a C1-6 alkoxy C1-6 alkyl group, a C1-6 alkoxy C1-6 alkoxy group, a halogenated C1-6 alkoxy C1-6 alkyl group, a hydroxy C1-6 alkoxy C1-6 alkoxy group, a hydroxy halogenated C1-6 alkoxy group, a C1-6 alkoxy carbonyl group, a C1-6 alkoxy carbonyl C1-6 alkyl group, a carboxy group, a —C(═O)NH2 group, a C3-8 cycloalkyl group (the C3-8 cycloalkyl group may have 1 to 3 substituent groups arbitrarily selected from a hydroxyl group, a halogen atom, a C1-6 alkyl group, a C1-6 alkoxy group, and a C1-6 alkoxy C1-6 alkyl group), a C6-10 aryl group (may have 1 to 3 substituent groups arbitrarily selected from a hydroxyl group, a cyano group, a halogen atom, a C1-6 alkyl group, a halogenated C1-6 alkyl group, a hydroxy C1-6 alkyl group, a C3-8 cycloalkyl group, a C1-6 alkoxy group, a halogenated C1-6 alkoxy group, a C1-6 alkoxy C1-6 alkyl group, a C1-6 alkoxy carbonyl group, a C2-6 alkanoyl group, a C1-6 alkylthio group, a C1-6 alkylsulfonyl group, a —NRαRβ group, a —CONRαRβ group (the Rα and Rβ are each independently a hydrogen atom, a C1-6 alkyl group, a halogenated C1-6 alkyl group, or a C3-8 cycloalkyl group), a carboxy group, and a —C(═O)NH2 group), a 5- or 6-membered heteroaryl group (the 5- or 6-membered heteroaryl group may have 1 to 3 substituent groups arbitrarily selected from a hydroxyl group, a cyano group, a halogen atom, a C1-6 alkyl group, a halogenated C1-6 alkyl group, a hydroxy C1-6 alkyl group, a C3-8 cycloalkyl group, a C1-6 alkoxy group, a halogenated C1-6 alkoxy group, a C1-6 alkoxy C1-6 alkyl group, a C2-6 alkanoyl group, a C1-6 alkylthio group, a C1-6 alkylsulfonyl group, a —NRαRβ group, a —NRαRβ group (the Rα and Rβ are each independently a hydrogen atom, a C1-6 alkyl group, a halogenated C1-6 alkyl group, or a C3-8 cycloalkyl), a carboxy group, and a —C(═O)NH2 group), a non-aromatic heterocyclic group (the non-aromatic heterocyclic group may each 1 to 3 substituent groups arbitrarily selected from a hydroxyl group, a cyano group, a halogen atom, a C1-6 alkyl group, a halogenated C1-6 alkyl group, a hydroxy C1-6 alkyl group, a C3-8 cycloalkyl group, a C1-6 alkoxy group, a halogenated C1-6 alkoxy group, a C1-6 alkoxy C1-6 alkyl group, a C1-6 alkoxy carbonyl group, a C2-6 alkanoyl group, a C1-6 alkylthio group, a C1-6 alkylsulfonyl group, a —NRαRβ group, a —NRαRβ group (the Rα and Rβ are each independently a hydrogen atom, a C1-6 alkyl group, a halogenated C1-6 alkyl group, or a C3-8 cycloalkyl group), a carboxy group, and a —C(═O)NH2 group), a —NR4eR4f group, a —CONR4eR4f group (the R4e and R4f are each independently a hydrogen atom, a C1-6 alkyl group, a hydroxy C1-6 alkyl group, a halogenated C1-6 alkyl group, a hydroxy halogenated C1-6 alkyl group, a C3-8 cycloalkyl group, or a 5- or 6-membered heteroaryl C1-6 alkyl group (the 5- or 6-membered heteroaryl in the 5- or 6-membered heteroaryl C1-6 alkyl group may have 1 to 3 substituent groups arbitrarily selected from a halogen atom and a C1-6 alkyl group)), a R4cR4dN—C1-6 alkoxy group (the R4c and R4d are each independently a hydrogen atom, a C1-6 alkyl group, a hydroxy C1-6 alkyl group, or a halogenated C1-6 alkyl group), a halogenated mono-/di-C2-7 alkanoyl amino group, a C1-6 alkylthio group, a C1-6 alkylsulfonyl group, and a halogenated C1-6 alkylsulfonyl group).