Antibiotic sensitivity-restoring and photosensitive agents
AssigneeNew Mexico Tech University Research Park Corporation
InventorsSnezna ROGELJ, Liliya FROLOVA, Alexander KORNIENKO, Leslie D. EDWARDS, Cody CHAMPION, Kailee ZINGLER, Danielle Nicole Turner
Life of this patent
Estimating the term…
Abstract
The present disclosure describes a method to treat conditions, including bacterial infections and cancer, using a photosensitive compound that, upon exposure to white light, can be activated. The photosensitive compound can also interact synergistically with antibiotics used concomitantly to kill drug-resistant bacteria. The photosensitive compounds can also be used to inhibit the proliferation of cancer cells.
Claims21
1-52. (canceled)
A method of treating a condition, the method comprising administering to a subject in need thereof a therapeutically-effective amount of a compound and a therapeutically-effective amount of a second agent, wherein the compound is of the formula:
- wherein:
- R1 is hydrogen or an ester group;
- R2 is hydrogen, halogen, or L1-Ar1;
- R3 is hydrogen, halogen, or L2-Ar2;
- each L1 and L2 is independently alkylene, alkenylene, O, S, SO2, CO, N2 or a bond;
- Ar1 is a substituted or unsubstituted aryl group;
- Ar2 is a substituted or unsubstituted aryl group wherein Ar2 is not substituted with an amide, amine, nitro, imine, or ester group;
- each A1, A2, A3, and A4 is independently C(R1a), C(R1a)(R1b), N, or N(R1a);
- each R1a and R1b is independently hydrogen, halogen, hydroxyl, sulfhydryl, nitro, nitroso, cyano, azido, a sulfoxide group, a sulfone group, a sulfonamide group, a sulfonic acid group, an imine group, an acyl group, an acyloxy group, alkyl, alkenyl, alkynyl, an alkoxy group, an ether group, a carboxylic acid group, a carboxaldehyde group, an ester group, an amine group, an amide group, a carbonate group, a carbamate group, a thioether group, a thioester group, a thioacid group, aryl, aryloxy, arylalkyl, arylalkoxy, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl, any of which is substituted or unsubstituted;
- and
- each is independently a single or double bond,
- or a pharmaceutically-acceptable salt thereof, wherein the compound is not:
The method of claim 1, wherein the compound is of the formula:
- wherein:
- R1 is hydrogen;
- R2 is hydrogen or L1-Ar1;
- R3 is L2-Ar2;
- and
- each A1, A2, A3, and A4 is independently C(R1a) or N,
- or a pharmaceutically-acceptable salt thereof.
Dependencies are inferred from the claim text.