Compositions and methods of regulating cancer related disorders and diseases
AssigneeOnco Therapies LLC
InventorsAnshu VASHISHTHA, Malini VASHISHTHA
Life of this patent
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Abstract
Provided herein are naphthylic derivative compounds, or pharmaceutically acceptable salts thereof, that are useful for inhibiting cancers. Also provided herein are methods of using effective amounts of said compounds, optionally with pharmaceutical carriers, for the treatment of cancers within human subjects.
Claims25
A compound, or a pharmaceutically acceptable salt thereof, having the structure of Formula I:
- wherein,
- R1 and R3 are either hydrogen or alkyl groups;
- R4 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, or substituted or unsubstituted alkyl chains terminating in a substituted or unsubstituted aryl;
- R2 is a substituted or unsubstituted naphthyl group optionally linked by a substituted or unsubstituted alkyl chain;
- wherein,
- each Y1-Y8 are independently selected from hydrogen, deuterium, halogen (F, Cl, Br, I), hydroxyl, alkoxy, nitrogenous substituents such as primary amines, substituted secondary and tertiary amines, sulfurous substituents including SH, sulfoxides, sulfones, sulfonamides, substituted or unsubstituted alkyl and substituted or unsubstituted aryls.
A method of administering a therapeutically effective amount of a compound, wherein the compound is selected from the group consisting of:
- 1-(naphthalen-1-yl)propan-2-amine;
- 1-naphthalen-1-yl)ethan-1-amine;
- 1-(naphthalen-2-yl)ethan-1-amine;
- 1-(6-methoxynaphthalen-2-yl)ethan-1-amine;
- 1-(1-amino-2-methylpropyl)naphthalen-2-ol;
- 1-(naphthalen-2-yl)propan-2-amine;
- 4-(2-((1-(naphthalen-1-yl)propan-2-yl)amino)ethyl)phenol;
- 4-((1-(naphthalen-1-yl)propan-2-yl)amino)phenol;
- 4-((1-(naphthalen-2-yl)propan-2-yl)amino)phenol;
- 4-(1-hydroxy-2-((1-(naphthalen-1-yl)propan-2-yl)amino)ethyl)phenol;
- 2-((1-(naphthalen-2-yl)propan-2-yl)amino)-1-phenylethan-1-ol;
- 4-(2-((1-(naphthalen-2-yl)propan-2-yl)amino)ethyl)phenol;
- 3-(1-hydroxy-2-((1-(naphthalen-1-yl)propan-2-yl)amino)ethyl)phenol;
- 3-(1-hydroxy-2-((1-(naphthalen-2-yl)propan-2-yl)amino)ethyl)phenol;
- 4-(1-hydroxy-2-((1-(naphthalen-2-yl)propan-2-yl)amino)ethyl)benzene-1,2-diol;
- 4-(1-hydroxy-2-((1-(naphthalen-1-yl)propan-2-yl)amino)ethyl)benzene-1,2-diol;
- 4-(1-hydroxy-2-((1-(naphthalen-2-yl)propan-2-yl)amino)ethyl)phenol;
- 4-(1-hydroxy-2-((1-(naphthalen-1-yl)propan-2-yl)amino)ethyl)phenol;
- 2-(1-hydroxy-2-((1-(naphthalen-1-yl)propan-2-yl)amino)ethyl)phenol;
- 2-(1-hydroxy-2-((1-(naphthalen-2-yl)propan-2-yl)amino)ethyl)phenol;
- 4-(2-((1-(4-methylnaphthalen-1-yl)propan-2-yl)amino)ethyl)phenol;
- 4-(2-((1-(5-methylnaphthalen-1-yl)propan-2-yl)amino)ethyl)phenol;
- 4-(1-hydroxy-2-((1-(4-methylnaphthalen-1-yl)propan-2-yl)amino)ethyl)benzene-1,2-diol;
- 3-(1-hydroxy-2-((1-(4-methylnaphthalen-1-yl)propan-2-yl)amino)ethyl)phenol;
- 2-((1-(4-methylnaphthalen-1-yl)propan-2-yl)amino)-1-phenylethan-1-ol;
- 4-(1-hydroxy-2-((1-(4-methylnaphthalen-1-yl)propan-2-yl)amino)ethyl)phenol;
- 4-(((1-(4-methylnaphthalen-1-yl)propan-2-yl)amino)methyl)phenol;
- 4-(((1-(naphthalen-1-yl)propan-2-yl)amino)methyl)phenol and 4-(((1-(naphthalen-2-yl)propan-2-yl)amino)methyl)phenol.
A method of administering a therapeutically effective amount of 1-(naphthalen-2-yl)propan-2-amine or 4-(2-((1-(naphthalen-1-yl)propan-2-yl)amino)ethyl)phenol.
A method of administering a therapeutically effective amount of a compound, wherein the compound is selected from the group consisting of:
- 1-(naphthalen-1-yl)propan-2-amine;
- 1-naphthalen-1-yl)ethan-1-amine;
- 1-(naphthalen-2-yl)ethan-1-amine;
- 1-(6-methoxynaphthalen-2-yl)ethan-1-amine;
- 1-(1-amino-2-methylpropyl)naphthalen-2-ol;
- 1-(naphthalen-2-yl)propan-2-amine;
- 4-(2-((1-(naphthalen-1-yl)propan-2-yl)amino)ethyl)phenol;
- 4-((1-(naphthalen-1-yl)propan-2-yl)amino)phenol;
- 4-((1-(naphthalen-2-yl)propan-2-yl)amino)phenol;
- 4-(1-hydroxy-2-((1-(naphthalen-1-yl)propan-2-yl)amino)ethyl)phenol;
- 2-((1-(naphthalen-2-yl)propan-2-yl)amino)-1-phenylethan-1-ol;
- 4-(2-((1-(naphthalen-2-yl)propan-2-yl)amino)ethyl)phenol;
- 3-(1-hydroxy-2-((1-(naphthalen-1-yl)propan-2-yl)amino)ethyl)phenol;
- 3-(1-hydroxy-2-((1-(naphthalen-2-yl)propan-2-yl)amino)ethyl)phenol;
- 4-(1-hydroxy-2-((1-(naphthalen-2-yl)propan-2-yl)amino)ethyl)benzene-1,2-diol;
- 4-(1-hydroxy-2-((1-(naphthalen-1-yl)propan-2-yl)amino)ethyl)benzene-1,2-diol;
- 4-(1-hydroxy-2-((1-(naphthalen-2-yl)propan-2-yl)amino)ethyl)phenol;
- 4-(1-hydroxy-2-((1-(naphthalen-1-yl)propan-2-yl)amino)ethyl)phenol;
- 2-(1-hydroxy-2-((1-(naphthalen-1-yl)propan-2-yl)amino)ethyl)phenol;
- 2-(1-hydroxy-2-((1-(naphthalen-2-yl)propan-2-yl)amino)ethyl)phenol;
- 4-(2-((1-(4-methylnaphthalen-1-yl)propan-2-yl)amino)ethyl)phenol;
- 4-(2-((1-(5-methylnaphthalen-1-yl)propan-2-yl)amino)ethyl)phenol;
- 4-(1-hydroxy-2-((1-(4-methylnaphthalen-1-yl)propan-2-yl)amino)ethyl)benzene-1,2-diol;
- 3-(1-hydroxy-2-((1-(4-methylnaphthalen-1-yl)propan-2-yl)amino)ethyl)phenol;
- 2-((1-(4-methylnaphthalen-1-yl)propan-2-yl)amino)-1-phenylethan-1-ol;
- 4-(1-hydroxy-2-((1-(4-methylnaphthalen-1-yl)propan-2-yl)amino)ethyl)phenol;
- 4-(((1-(4-methylnaphthalen-1-yl)propan-2-yl)amino)methyl)phenol;
- 4-(((1-(naphthalen-1-yl)propan-2-yl)amino)methyl)phenol and 4-(((1-(naphthalen-2-yl)propan-2-yl)amino)methyl)phenol or a combination thereof.
A method of administering a therapeutically effective amount of 1-(naphthalen-2-yl)propan-2-amine or 4-(2-((1-(naphthalen-1-yl)propan-2-yl)amino)ethyl)phenol or a combination thereof.
Dependencies are inferred from the claim text.