Magnetic Separation Filters For Microfluidic Devices
AssigneeThe Trustees of the University of Pennsylvania
InventorsDavid Aaron Issadore, Melaku Muluneh Woldemariam
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Abstract
A magnetic separation device has a membrane having a plurality of pores, a magnetically soft material layer disposed on the membrane, and a passivation layer disposed on the magnetically soft material layer. The magnetic separation device may be part of a microfluidic device having a lateral flow channel and a vertical flow magnetic separation filter. The magnetic separation device may be used to separate magnetically tagged particles, such as cells.
Claims24
A magnetic separation device comprising:
- a membrane including a plurality of pores;
- a layer of magnetically soft material adjacent the membrane;
- and
- a passivation layer adjacent the layer of magnetically soft material;
- wherein the plurality of pores extend through the layer of magnetically soft material and through the passivation layer.
A microfluidic device comprising:
- at least one lateral flow channel;
- and
- at least one vertical flow magnetic separation filter in fluidic communication with the at least one lateral flow channel;
- wherein the at least one vertical flow magnetic separation filter comprises:
- (i) a membrane including a plurality of pores;
- (ii) a layer of magnetically soft material adjacent the membrane;
- and (iii) a passivation layer adjacent the layer of magnetically soft material, wherein the plurality of pores extend through the layer of magnetically soft material and through the passivation layer.
A method for separating magnetically tagged particles, comprising:
- flowing a suspension comprising the magnetically tagged particles through a magnetic separation device comprising:
- (i) a membrane including a plurality of pores;
- (ii) a layer of magnetically soft material adjacent the membrane;
- and (iii) a passivation layer adjacent the layer of magnetically soft material, wherein the plurality of pores extend through the layer of magnetically soft material and through the passivation layer;
- capturing the magnetically tagged particles by exposing the magnetic separation device to an external magnetic field;
- and
- releasing the magnetically tagged particles by removing the external magnetic field.
Dependencies are inferred from the claim text.