Systems and methods for percutaneous nerve stimulation
AssigneeDuke University
InventorsNiccolo Terrando, William Huffman, Warren Grill
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Abstract
The present disclosure provides systems and methods relating to neuromodulation. In particular, the present disclosure provides systems and methods for minimally invasive, targeted, vagus nerve stimulation (pVNS), and the efficacy of this approach with respect to microglial activation and the amelioration of cognitive dysfunction. The systems and methods of neuromodulation disclosed herein can be used to facilitate the treatment of various diseases associated with pathological neural activity.
Claims31
A percutaneous neuromodulation system comprising:
- a needle electrode sized and configured for percutaneous placement in proximity to neural tissue in a subject;
- and
- a pulse generator coupled to the needle electrode, the pulse generator comprising a power source and a microprocessor, wherein the pulse generator provides to the needle electrode a plurality of charge-balanced pulses to stimulate the neural tissue.
A method of treating or preventing a neurological disorder, the method comprising:
- placing a needle electrode in proximity to neural tissue in a subject, wherein the needle electrode is placed percutaneously;
- and
- instructing a pulse generator coupled to the needle electrode to provide to the needle electrode a plurality of charge-balanced pulses to stimulate the neural tissue;
- wherein stimulating the neural tissue treats or prevents the neurological disorder in the subject.
Dependencies are inferred from the claim text.