Bone-promoting thermoresponsive macromolecules
AssigneeNorthwestern University
InventorsGuillermo A. Ameer, Simona Morochnik
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Abstract
Provided herein are injectable, thermoresponsive hydrogels that are liquid at room temperature, provide a carrier material, and gel at body temperature to allow for controlled release. In particular, PPCN-based hydrogels are provided with therapeutic agents (e.g., drugs, ions, etc.) incorporated within or appended thereto, and methods of preparation and use thereof, for example, for the promotion of bone formation/repair and/or the treatment of bone diseases.
Claims23
A composition comprising a PPCN-based hydrogel comprising citric acid, poly(ethylene glycol), glycerol 1,3-diglycerolate diacrylate, and poly-(N-isopropylacrylamide) monomers and at least one bioactive agent incorporated therein and/or appended thereto.
A composition comprising a PPCN-based phosphate-displaying hydrogel comprising citric acid, poly(ethylene glycol), glycerol 1,3-diglycerolate diacrylate, poly-(N-isopropylacrylamide), and β-glycerophosphate monomers.
A composition comprising a PPCN-based peptide-displaying hydrogel comprising citric acid, poly(ethylene glycol), glycerol 1,3-diglycerolate diacrylate, and poly-(N-isopropylacrylamide) monomers, and a peptide covalently conjugated to carboxy groups of the citric acid monomers.
A composition comprising a PPCN-based hydrogel comprising citric acid, poly(ethylene glycol), glycerol 1,3-diglycerolate diacrylate, and poly-(N-isopropylacrylamide) monomers, and metal ion crosslinks.
Dependencies are inferred from the claim text.