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US 2019/0336647 A1Published application
Thin film interposition of basement membrane scaffolds
AssigneeIVIVA Medical, Inc.
InventorCharles C. Klassen
Life of this patent
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Abstract
Disclosed are compositions and methods of making basement membrane constructs having interior or luminal volumes. The interior or luminal volumes may be in the form of vascular networks for liquid (e.g., blood) or gas perfusion. The interior spaces may also contain cells, such as epithelial cells. Also disclosed are tissues and organs, and methods of making thereof, comprising basement membrane constructs.
Claims55
A composition comprising a thin film defining an interior volume, wherein the thin film comprises functional basement membrane material.
A method of making a basement membrane construct, comprising:
- a. generating a sacrificial structure comprising one or more sacrificial materials on a support structure or a thin film layer;
- b. applying a thin film layer comprising functional basement membrane material to the sacrificial structure;
- c. optionally repeating steps (a) and then (b) one or more times;
- d. optionally embedding the product of steps (a), (b) and optionally (c) in a sacrificial or permanent material;
- and
- e. removing the sacrificial material to provide one or more interior volumes, thereby making a basement membrane construct.
3 more elements
Dependencies are inferred from the claim text.