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US 2019/0336645 A1Published application
Recombinant polypeptides, compositions, and methods thereof
AssigneesBioGend Therapeutics Co., Ltd., Osteopharma Inc.
InventorsDA-WEI SUN, PEI-WEN HSU, CHIEN-PEI CHEN
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Abstract
The present disclosure provides recombinant polypeptides, homodimeric and heterodimeric proteins comprising the recombinant polypeptides, nucleic acid molecules encoding the recombinant polypeptides, and vectors and host cells comprising the nucleic acid molecules. The present disclosure also provides compositions comprising the recombinant polypeptides and methods of making and using the recombinant polypeptides.
Claims18
A recombinant polypeptide comprising:
- a first domain selected from the group consisting of SEQ ID NO:
- 35 and SEQ ID NO:
- 39;
- a second domain selected from the group consisting of SEQ ID NO:
- 47 and SEQ ID NO:
- 49;
- and
- a third domain selected from the group consisting of SEQ ID NO:
- 57 and SEQ ID NO:
- 61;
- wherein the first domain is fused to either C-terminal or N-terminal of the second domain, the third domain is fused to the second domain, the first domain or both of the first and the second domains, and wherein the recombinant polypeptide is capable of inducing alkaline phosphatase activity.
8 more elements
A recombinant polypeptide comprises an amino acid sequence selected from the group consisting of:
- SEQ ID NO:
- 260, SEQ ID NO:
- 268, SEQ ID NO:
- 276, SEQ ID NO:
- 284, SEQ ID NO:
- 292, SEQ ID NO:
- 300, SEQ ID NO:
- 308, SEQ ID NO:
- 316, SEQ ID NO:
- 324, SEQ ID NO:
- 332, SEQ ID NO:
- 340, and SEQ ID NO:
- 348, wherein the recombinant polypeptide is capable of inducing alkaline phosphatase activity.
10 more elements
Dependencies are inferred from the claim text.