Glucose-sensitive peptide hormones

A conjugate of the formula P-L-I, wherein P is a peptide hormone effecting the metabolism of carbohydrates in vivo, L is a hydrolysable linker molecule consisting of Lp and Li, and I is a molecule capable of inactivating or inhibiting the effect of the peptide hormone P on the metabolism of carbohydrates in vivo, wherein

• a. the linker molecule L is hydrolysable in vivo, such that the conjugate P-L-I and the conjugate parts P-Lp and Li-I exist in a dynamic equilibrium in vivo where the conjugate P-L-I exists in molar excess of at least one of the conjugate parts P-Lp and Li-I, and further characterised in that
• b. at least one of the conjugate parts P-Lp and Li-I binds covalently to glucose, whereby the concentration of P that is not bound to I increases in vivo when the concentration of glucose increases in vivo, or, alternatively further wherein the hydrolysis of the hydrolysable linker L is being promoted by glucose.