Cationic carriers for nucleic acid delivery
AssigneeCureVac AG
InventorsPatrick BAUMHOF, Carolin THIELE
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Abstract
Compositions for nucleic acid delivery are provided which comprise a relatively low amount a permanently cationic lipid or lipidoid, such as a lipid comprising a quaternary ammonium group. The compositions are suitable for the delivery of chemically modified or unmodified DNA or RNA. Moreover, the compositions are suitable for local administration, such as by extravascular injection.
Claims27
A composition comprising
- (a) a cationisable or permanently cationic lipid or lipidoid, and
- (c) a nucleic acid compound;
- wherein the lipid or lipidoid and the nucleic acid compound are non-covalently associated, and wherein the ratio of the lipid or lipidoid to the nucleic acid compound is not higher than about 2 nmol lipid per μg nucleic acid compound.
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A permanently cationic lipidoid comprising the cation depicted in the formula IV:
- further optionally comprising a pharmaceutically acceptable anion.
A cationisable lipidoid comprising the compound depicted in formula IVa:
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Dependencies are inferred from the claim text.