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US 2019/0336606 A1Published application
High capacity diketopiperazine microparticles and methods
AssigneeMannKind Corporation
InventorsMarshall Grant, Paul Menkin, Grayson W. Stowell
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Abstract
Disclosed herein are diketopiperazine microparticles having high capacity for adsorbing a drug or active agent. In particular, the diketopiperazine microparticle are formed using fumaryl diketopiperazine and can comprise a drug in large doses for the treatment of disease or disorders by pulmonary delivery via oral inhalation.
Claims13
An inhalable dry powder comprising diketopiperazine microparticles and a drug or an active agent;
- wherein each of the diketopiperazine microparticles comprises a plurality of structural domains, each structural domain comprising a nucleus surrounded by layers of a porous crystalline material, and said diketopiperazine microparticles have a mass-weighted average particle size of about 33,000 to about 216,000 voxels measured by X-ray tomography for particle size measuring about 0.5 μm to about 4 μm in geometric diameter.
Dependencies are inferred from the claim text.