Biodegradable light-activatable drug delivery implant
AssigneeUniversity of Cincinnati
InventorsYoonjee Park, Xingyu He
Life of this patent
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Abstract
An implant device includes a polymer tube including an enclosed inner space, and a mixture of a hydrogel and a plurality of nanoparticles within the enclosed inner space. Each of the plurality of nanoparticles includes a shell, payload within the shell, and one or more photothermal agents on a surface of the shell. A wall of the polymer tube includes one or more layers of nanoporous polymer sheets including a plurality of pores. The dimension of the nanoparticles is greater than the dimension of the pores, and the dimension of the payload is smaller than the dimension of the pores.
Claims20
An implant device comprising:
- a polymer tube including an enclosed inner space;
- and
- a mixture of a hydrogel and a plurality of nanoparticles within the enclosed inner space,
- wherein each of the plurality of nanoparticles includes:
- a shell;
- payload within the shell;
- and
- one or more photothermal agents on a surface of the shell.
A method for manufacturing an implant device, the method comprising:
- dissolving a polymer and a porogen in an organic solvent;
- spreading the dissolved polymer and the porogen on a surface to create a nanoporous polymer sheet including a plurality of pores;
- rolling the nanoporous polymer sheet to create a polymer tube;
- injecting a plurality of LAPs into the polymer tube;
- and
- sealing both ends of the polymer tube,
- wherein each of the plurality of LAPs includes:
- a shell;
- payload within the shell;
- and
- one or more photothermal agents on a surface of the shell.
A method for releasing payload in an implant device, the method comprising:
- placing the implant device in a syringe needle;
- injecting the implant device into an object;
- and
- irradiating a laser at the implant device,
- wherein the implant device comprise:
- a polymer tube including an inner space;
- and
- a mixture of a hydrogel and a plurality of nanoparticles within the inner space, wherein each of the plurality of LAPs includes:
- a shell;
- payload within the shell;
- and
- one or more photothermal agents on a surface of the shell.
Dependencies are inferred from the claim text.