Back to results
US 2019/0336596 A1Published application
Universal vaccine platform
AssigneeArizona Board of Regents on behalf of Arizona State University
InventorsHugh Mason, Andrew Diamos, Mary Pardhe
Life of this patent
Estimating the term…
Abstract
The disclosure relates to vaccination compositions, for example, against human papillomavirus, Zika virus, and flu virus. The disclosure also relates to vectors for producing the virus-like particles and immune complex platforms of the vaccination compositions.
Claims20
A vaccination composition, the composition comprising:
- a virus-like particle (VLP), wherein the VLP comprises:
- a first hepatitis B virus core antigen (HBcAg) monomer;
- a second HBcAg monomer, wherein the first HBcAg monomer and the second HBcAg monomer forms a HBcAg dimer, and the HBcAg dimer forms the VLP core;
- and
- a first fragment of a virus protein, wherein the first fragment of the virus protein is linked to the major insertion region of the second HBcAg monomer;
- and
- at least one recombinant immune complex (RIC), wherein the RIC comprises:
- an immunoglobulin heavy chain;
- an epitope tag, wherein the immunoglobulin heavy chain binds the epitope tag;
- and
- a second fragment of the virus protein.
8 more elements
A method of generating an immune response against a virus in a mammalian subject, the method comprising:
- administering to the mammalian subject a virus-like particle (VLP), wherein the VLP comprises:
- a first hepatitis B virus core antigen (HBcAg) monomer;
- a second HBcAg monomer, wherein the first HBcAg monomer and the second HBcAg monomer forms a HBcAg dimer, and the HBcAg dimer forms the VLP core;
- and
- a first fragment of a virus protein, wherein the first fragment of the virus protein is linked to the major insertion region of the second HBcAg monomer;
- and
- administering to the mammalian subject at least one recombinant immune complex (RIC), wherein the RIC comprises:
- an immunoglobulin heavy chain;
- an epitope tag, wherein the immunoglobulin heavy chain binds the epitope tag;
- and
- a second fragment of the virus protein.
8 more elements
Dependencies are inferred from the claim text.