Immunizing peptide, method for producing immunizing peptide, pharmaceutical composition for immune disease containing same, and method for treating immune disease

A method for designing an immunizing peptide, comprising

• designing a candidate peptide for the immunizing peptide;
• and
• administering the candidate peptide into a living organism;
• and
• determining whether the candidate peptide induces production of an antibody to a complex of the candidate peptide and an MHC molecule of the living organism as the immunizing peptide, wherein
• the candidate peptide comprises a T-cell epitope of a target protein and an antibody-inducing portion of the target protein, and
• the antibody-inducing portion is at least one of the following amino acid residues in an amino acid sequence of the target protein:
• one or more contiguous amino acid residues immediately upstream of a N-terminal amino acid residue of the T-cell epitope;
• and one or more contiguous amino acid residues immediately downstream of a C-terminal amino acid residue of the T-cell epitope.

A method of producing an antibody, the method comprising:

• administering an immunizing peptide to a living organism, thereby inducing a production of an antibody that binds to a complex of the immunizing peptide included in an antibody production inducing agent and an MHC molecule of the living organism, wherein
• the immunizing peptide comprises:
• a T-cell epitope of a target protein;
• and
• an antibody-inducing portion of the target protein, and
• the antibody-inducing portion is at least one of the following amino acid residues in an amino acid sequence of the target protein:
• one or more contiguous amino acid residues immediately upstream of an N-terminal amino acid residue of the T-cell epitope;
• and one or more contiguous amino acid residues immediately downstream of a C-terminal amino acid residue of the T-cell epitope.