Immunostimulatory compositions and uses therefor
AssigneeBoard of Supervisors of Louisiana State University and Agricultural and Mechanical College
InventorsRonald James Jackson, Charani Ranasinghe
Life of this patent
Estimating the term…
Abstract
Disclosed are compositions and methods for stimulating immune responses. More particularly, these compositions and methods involve the use of an inhibitor of IL-25 function and an immune stimulator that stimulates an immune response to a target antigen for stimulating protective or therapeutic immune responses to a target antigen. The compositions and methods of the present invention are particularly useful in the prevention and treatment of infections and cancers.
Claims52
An immunostimulatory composition comprising a first agent comprising an immune stimulator or a polynucleotide sequence from which a nucleotide sequence encoding an immune stimulator is expressible, wherein the immune stimulator stimulates or otherwise enhances an immune response to a target antigen in a subject, together with a second agent comprising an inhibitor of IL-25 function or a polynucleotide from which a nucleotide sequence encoding an inhibitor of IL-25 function is expressible.
A kit comprising a priming composition comprising a first agent comprising an immune stimulator or a polynucleotide from which a nucleotide sequence encoding an immune stimulator is expressible, wherein the immune stimulator stimulates or otherwise enhances an immune response to a target antigen in a subject, and a boosting composition comprising the immune stimulator together with a second agent comprising an inhibitor of IL-25 function or a polynucleotide from which a nucleotide sequence encoding an inhibitor of IL-25 function is expressible.
(canceled)
(canceled)
(canceled)
A method of treating a disease or condition associated with the presence of aberrant expression of a target antigen in a subject comprising administering a first agent comprising an immune stimulator that stimulates or otherwise enhances an immune response to the target antigen or a polynucleotide sequence encoding an immune stimulator that stimulates or otherwise enhances an immune response to the target antigen and administering a second agent comprising an inhibitor of IL-25 function or a polynucleotide sequence encoding an inhibitor of IL-25 function.
An immunostimulatory antigen-presenting cell or antigen-presenting cell precursor which presents an antigen that corresponds to at least a portion of a target antigen, and which expresses or otherwise produces an inhibitor of IL-25 function.
A method of eliciting an immune response to a target antigen in a subject, the method comprising:
- (1) administering a first composition that comprises a first agent that comprises an immune stimulator that stimulates or otherwise enhances an immune response to the target antigen or a polynucleotide sequence encoding an immune stimulator that stimulates or otherwise enhances an immune response to the target antigen;
- and (2) administering a second composition that comprises the first agent together with a second agent that comprises an inhibitor of IL-25 function or a polynucleotide sequence encoding an inhibitor of IL-25 function.
A method for enhancing mucosal immunity to a target antigen in a subject that is administered a first agent comprising an immune stimulator or a polynucleotide sequence from which a nucleotide sequence encoding an immune stimulator is expressible, wherein the immune stimulator stimulates or otherwise enhances an immune response to the target antigen, the method comprising systemically administering to the subject a second agent comprising an inhibitor of IL-25 function or a polynucleotide from which a nucleotide sequence encoding an inhibitor of IL-25 function is expressible, to thereby enhance mucosal immunity to the target antigen.
-53. (canceled)
Dependencies are inferred from the claim text.