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US 2019/0336580 A1Published application
Fusion Proteins Containing Insulin-Like Growth Factor-1 and Epidermal Growth Factor and Variants Thereof and Uses Thereof
AssigneeIGF Oncology, LLC
InventorHugh McTavish
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Abstract
Fusion proteins comprising cytokines, particularly insulin-like growth factor-1 (IGF-1) and variants thereof, epidermal growth factor (EGF), and other ligands to the EGF receptor, are provided. The fusion proteins further comprise SEQ ID NO:1 or other segments having lysine, glutamic acid, or aspartic acid residues. Uses for the fusion proteins are also provided.
Claims18
A method of treating cancer in a mammal comprising:
- administering to the mammal a compound comprising an anti-cancer chemotherapeutic agent covalently attached to a fusion polypeptide comprising:
- either SEQ ID NO:1 or residues 2-18 of SEQ ID NO:1;
- fused directly to the N-terminus of a cytokine;
- wherein the cytokine is a ligand to ErbB-1 or IGFR1.
1 more element
Dependencies are inferred from the claim text.