Back to results
US 2019/0336578 A1Published application
Platelet Activation and Growth Factor Release Using Electric Pulses
AssigneeGeneral Electric Company
InventorsVasile Bogdan Neculaes, Andrew Soliz Torres, Antonio Caiafa, Brian Dun-Lan Lee, Allen Lawrence Garner
Life of this patent
Estimating the term…
Abstract
Methods and systems for releasing growth factors are disclosed. In certain embodiments, a blood sample is exposed to a sequence of one or more electric pulses to trigger release of a growth factor in the sample. In certain embodiments, the growth factor release is not accompanied by clotting within the blood sample.
Claims9
A method for releasing growth factors, comprising:
- exposing a blood sample to a sequence of one or more electric pulses to trigger release of the growth factors in the blood sample, wherein the one or more electric pulses have an electric field strength between 0.1 kV/cm and 350 kV/cm and pulse durations between 1 nanosecond and 100 microsecond, wherein calcium chloride (CaCl2) is not added to the blood sample prior to or during the exposure of the blood sample to the sequence of one or more electric pulses, whereby the growth factor release is not accompanied by clotting within the blood sample;
- and
- collecting the released growth factors.
A method for releasing growth factors, comprising:
- adding calcium chloride (CaCl2) and an ADP blocking agent to a blood sample;
- exposing the blood sample to a sequence of one or more electric pulses to trigger release of the growth factors in the blood sample, wherein the one or more electric pulses have an electric field strength between 0.1 kV/cm and 350 kV/cm and pulse durations between 1 nanosecond and 100 microseconds, and wherein the growth factor release is not accompanied by clotting within the blood sample;
- and
- collecting the released growth factors.
1 more element
Dependencies are inferred from the claim text.