Reversing deficient hedgehog signaling restores deficient skeletal regeneration
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsMichael T. Longaker, Irving L. Weissman, Ruth Tevlin, Charles K.F. Chan
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Abstract
Methods and compositions are provided for the therapeutic use of hedgehog agents, for enhancing bone growth and regeneration in diabetic or pre-diabetic patients, including repair following injury, osseointegration of implants, and the like. In some embodiments of the invention, the compositions are administered locally, e.g. by injection or implantation at the site of an injury.
Claims21
A method of enhancing bone repair in an individual with diabetes or pre-diabetes, the method comprising:
- administering to the individual an effective dose of a hedgehog agent at a site of desired bone repair in the mammal.
The method of claim 1, wherein the hedgehog agent is implanted or injected at the site of desired bone repair.
The method of claim 10, wherein the hedgehog agent is entrapped in a sustained or localized release formulation.
A method of countering osteoporosis in a diabetic patient, the method comprising
- administering systemically to the individual an effective dose of a hedgehog agent.
Dependencies are inferred from the claim text.