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US 2019/0336570 A1Published application
Formulations of vancomycin
AssigneeScidose LLC
InventorsNagesh R. Palepu, Philip Christopher Buxton
Life of this patent
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Abstract
Liquid vancomycin containing compositions having extended shelf life are disclosed. The compositions contain vancomycin or a pharmaceutically acceptable salt thereof, a polyol such as glycerol, and lactic acid or a lactate. The compositions are ready to use and easily transferred into larger parenteral solutions prior to administration to patients in need thereof.
Claims14
A method of providing a dose of a liquid vancomycin-containing composition, comprising:
- a) providing a liquid vancomycin-containing composition, comprising about 200 mg/mL of vancomycin or a pharmaceutically acceptable salt thereof, about 25 to 30% (v/v) glycerol, a member of the group consisting of lactic acid, lactate or mixtures thereof, a base and water, the liquid vancomycin composition having a pH of from about 4.5 to about 7.5;
- and
- b) diluting the liquid vancomycin-containing composition with a pharmaceutically acceptable liquid to concentration of about 5 mg/ml of vancomycin.
Dependencies are inferred from the claim text.