Compositions for Inhibiting PP2A Demethylation

A method of preparing a botanical extract comprising:

• (a) introducing a raw botanical to a solvent having a dielectric constant ranging from about 2.3 to about 25 and allowing the mixture to reside for a sufficient time to obtain a crude extract;
• (b) filtering out remaining raw botanical and evaporating the solvent from the crude extract under reduced pressure to obtain a dried crude extract;
• (c) washing the dried crude extract with a polar solvent having a dielectric constant of no less than 30, heating the resulting mixture, and allowing to cool to ambient;
• (d) collecting a filtrate from the cooled mixture from step (c);
• and
• (e) washing the collected filtrate with a non-polar solvent having a dielectric constant of no more than 2.0;
• and
• (f) filtering and drying the mixture from step (e) to obtain the botanical extract.