Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cells
AssigneeSynlogic Operating Company, Inc.
InventorsDean Falb, Jonathan W. Kotula, Vincent M. Isabella, Paul F. Miller, Suman Machinani, Saurabh Saha, Adam B. Fisher, Yves Millet, Ning Li, Jose M. Lora
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Abstract
Genetically programmed microorganisms, such as bacteria or virus, pharmaceutical compositions thereof, and methods of modulating and treating cancers are disclosed.
Claims21
-136. (canceled)
A genetically engineered bacterium comprising at least one non-native gene sequence encoding an enzyme capable of producing a stimulator of interferon gene (STING) agonist.
A genetically engineered bacterium comprising at least one gene sequence encoding an effector molecule, wherein the effector molecule is selected from the group consisting of CXCL9, CXCL10, hyaluronidase, and SIRPα, wherein the effector molecule is secreted or displayed on the cell surface.
A genetically engineered bacterium comprising at least one gene sequence encoding an enzyme capable of converting 5-FC to 5-FU.
A genetically engineered bacterium capable of secreting a dimerized IL-12, wherein the modified microorganism comprises a gene sequence comprising a p35 IL-12 subunit gene sequence linked to a p40 IL-12 subunit gene sequence by a linker sequence, and a secretion tag sequence.
A genetically engineered bacterium capable of secreting an IL-15 fusion protein, wherein the modified microorganism comprises a gene sequence comprising an IL-15 gene sequence fused to a sushi domain sequence.
Dependencies are inferred from the claim text.