Pluripotent stem cell-derived oligodendrocyte progenitor cells for the treatment of spinal cord injury
AssigneeAsterias Biotherapeutics, Inc.
InventorsEdward D. Wirth, Jane S. Lebkowski, Nathan C. Manley
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Abstract
The present disclosure provides methods and compositions for making and using pluripotent stem cell-derived oligodendrocyte progenitor cells.
Claims20
A container containing a composition comprising a population of human pluripotent stem cell-derived oligodendrocyte progenitor cells (OPCs) that are capable of engrafting at a spinal cord injury site of a human subject following implantation of a dose of the composition into the spinal cord injury site.
A method of reducing spinal cord injury-induced parenchymal cavitation in a human subject with an acute spinal cord injury, the method comprising directly injecting into the spinal cord injury site of said subject a composition comprising human pluripotent stem cell-derived oligodendrocyte progenitor cells (OPCs) that are capable of engrafting at a spinal cord injury site.
Dependencies are inferred from the claim text.