Combined organ and hematopoietic cells for transplantation tolerance of grafts
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsSamuel Strober, Robert Lowsky
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Abstract
Methods and compositions are provided for combined transplantation of a solid organ and hematopoietic cells to a recipient, where tolerance to the graft is established through development of a persistent mixed chimerism. An individual with persistent mixed chimerism, usually for a period of at least six months, is able to withdraw from the use of immunosuppressive drugs after a period of time sufficient to establish tolerance.
Claims22
A method for establishing mixed chimerism in a solid organ transplant recipient, the method comprising:
- providing to the recipient of the solid organ transplant a cellular product comprising greater than 5×105 CD34+ cells/kg recipient weight, and greater than 1×105 CD3+ cells/kg recipient weight;
- and
- providing to the recipient of the solid organ transplant a cell type that facilitates engraftment of the cells of the cellular product in the bone marrow of the recipient of the solid organ transplant.
A method for establishing mixed chimerism in a solid organ transplant recipient, the method comprising:
- providing to the recipient of the solid organ transplant a cellular product comprising greater than 5×105 CD34+ cells/kg recipient weight, and a defined amount of CD3+ cells/kg recipient weight;
- and
- providing to the recipient of the solid organ transplant a cell type that facilitates engraftment of the cells of the cellular product in the bone marrow of the recipient of the solid organ transplant.
Dependencies are inferred from the claim text.