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US 2019/0336507 A1Published application
Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith
AssigneeSignal Pharmaceuticals, LLC
InventorsMatthew Alexander, Joshua Hansen, Dehua Huang, Robert Hubbard, Raj K. Raheja, Kimberly Schwarz, Marianne Sloss, Eduardo Torres, JingJing Zhao, Shuichan Xu, Sogole Bahmanyar
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Abstract
Provided herein are Aminopurine Compounds having the following structures: wherein R1, R2, and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound, and methods for treating or preventing a cancer, for example, melanoma.
Claims1
A compound of formula (Ia)
- wherein:
- R1 is substituted or unsubstituted C1-8 alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkylalkyl, or substituted or unsubstituted non-aromatic heterocyclyl;
- R2 is H or substituted or unsubstituted C1-3 alkyl;
- and
- R3 is phenyl, substituted with one or more halogen, optionally further substituted with one or more substituents selected from substituted or unsubstituted C1-3 alkyl, CN, and —OR′, wherein each R′ is independently substituted or unsubstituted C1-3 alkyl.
2 more elements
Dependencies are inferred from the claim text.