Novel crystalline forms of selinexor and process for their preparation
AssigneeWatson Laboratories, Inc.
InventorsAnantha Rajmohan MUTHUSAMY, Sundara Lakshmi KANNIAH, Akash RAVI, Tonmoy Chitta DAS, Rajendra Popat CHEMATE, Anil Kumar SINGH, Yogesh Dhananjay WAGH
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Abstract
The present disclosure relates to solid state forms of Selinexor, processes for preparation thereof and pharmaceutical compositions thereof.
Claims16
A crystalline form of Selinexor designated as Form T8, characterized by data selected from one or more of the following:
- a. an X-ray powder diffraction pattern having peaks at 6.0, 13.4, 17.6, 19.6, and 24.9 degrees 2-theta±0.2 degrees 2-theta;
- b. an XRPD pattern as depicted in FIG. 8;
- c. a solid state 13C-NMR spectrum having characteristic peaks at 107.5, 126.0, 132.2, 141.5, 151.7 and 157.9 ppm±0.2 ppm;
- d. a solid state 13C-NMR spectrum having the following chemical shift absolute differences from a reference peak at 154.1 ppm±2 ppm of 46.6, 28.1, 21.9, 12.6 , 2.4 and 3.8 ppm±0.1 ppm;
- e. a solid state 13C-NMR spectrum as depicted in FIG. 18 or 19 or 20;
- and
- f. a combination of any two or more of the above.
A crystalline form of Selinexor designated as Form T1, characterized by data selected from one or more of the following:
- a. an XRPD pattern having peaks 10.2, 16.9, 21.1, 21.5, 22.7, and 26.7 degrees 2-theta±0.2 degrees 2-theta;
- b. an XRPD pattern as depicted in FIG. 1;
- and
- c. a combination of (a) and (b).
A crystalline form of Selinexor designated as Form T6, characterized by data selected from one or more of the following:
- a. an XRPD pattern having peaks at 13.0, 13.7, 20.1, 23.2, 23.9 and 27.7 degrees 2-theta±0.2 degrees 2-theta;
- b. an XRPD pattern as depicted in FIG. 6;
- and
- c. a combination of (a) and (b).
A crystalline form of Selinexor designated as Form T7, characterized by data selected from one or more of the following:
- a. an XRPD pattern having peaks 15.1, 15.5, 21.6, 24.0 and 26.4-degrees 2-theta±0.2 degrees 2-theta;
- b. an XRPD pattern as depicted in FIG. 7;
- and
- c. a combination of (a) and (b).
Dependencies are inferred from the claim text.