Small molecules for inhibiting chemokine activity, a kinase activity and/or cancer cells growth
AssigneeBiokine Therapeutics Ltd.
InventorsAmnon PELED, Michal ABRAHAM, Orly EIZENBERG
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Abstract
Compounds capable of, or usable in, inducing death of cancer cells and/or modulating a biological activity of a chemokine e.g., cell migration, and/or treating diseases and disorders associated with a biological activity of a chemokine and/or cell migration, and/or inhibiting a kinase and/or in treating a disease or disorder associated with an activity of a kinase, such as cancer and inflammatory diseases and disorders, are provided herein. The compounds are collectively represented by Formulae Ia or Ib: wherein A, B D, E, G and R1-R5 are as defined in the specification.
Claims23
1-42. (canceled)
43-75. (canceled)
A compound represented by Formula Ia and/or Ib:
- wherein:
- A is an alkyl being at least 4 carbon atoms in length;
- B is selected from hydroxy and alkoxy;
- D, E and G are each independently selected from hydrogen, hydroxy, alkoxy and alkyl, provided that (i) no more than one of D, E and G is said alkyl, (ii) no more than two of D, E and G are said alkoxy, and (iii) if two of D, E and G are said alkoxy, none of D, E and G is said alkyl;
- R1 is selected from hydrogen and alkyl;
- and
- each of R2-R5 is independently selected from hydrogen, hydroxy, halo, alkoxy, thioalkoxy, thiol, thioalkoxy and amine.
Dependencies are inferred from the claim text.