Methods of treating bacterial infections
AssigneeRempex Pharmaceuticals, Inc.
InventorsJeffrey S. LOUTIT, Michael N. DUDLEY, Elizabeth E. MORGAN, Karen FUSARO, David C. GRIFFITH, Olga LOMOVSKAYA
Life of this patent
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Abstract
Methods of treating or ameliorating urinary tract infection (UTI), including complicated urinary tract infection (cUTI) and acute pyelonephritis (AP), comprising administering a composition comprising a cyclic boronic acid ester vaborbactam in combination with meropenem are disclosed herewith.
Claims72
A method of treating or ameliorating complicated urinary tract infection (cUTI) or acute pyelonephritis (AP) in a subject in need thereof, comprising administering a combination of an amount of vaborbactam or a pharmaceutically acceptable salt thereof and an amount of meropenem to the subject.
A method of treating or ameliorating complicated urinary tract infection (cUTI) or acute pyelonephritis (AP) in a subject in need thereof, comprising:
- selecting for treatment a subject having a systemic inflammatory response syndrome (SIRS) who is also suffering from cUTI or AP;
- and
- administering a combination of an amount of vaborbactam or a pharmaceutically acceptable salt thereof and an amount of meropenem to the subject.
A method of treating or ameliorating complicated urinary tract infection (cUTI) or acute pyelonephritis (AP) in a subject in need thereof, comprising:
- selecting for treatment a subject having a Charlson comorbidity score of equal to or greater than 3, who is also suffering from cUTI or AP;
- and
- administering a combination of an amount of vaborbactam or a pharmaceutically acceptable salt thereof and an amount of meropenem to the subject.
A method of treating or ameliorating a serious infection due to carbapenem-resistant enterobacteriaceae (CRE) in a subject in need thereof, comprising:
- selecting for treatment a subject having a CRE infection that requires at least 7 days of treatment with intravenous antibiotics;
- and
- administering a combination of an amount of vaborbactam or a pharmaceutically acceptable salt thereof and an amount of meropenem to the subject.
Dependencies are inferred from the claim text.