Small molecule bcl-2 functional converters as cancer therapeutics
AssigneeOregon State University
InventorsSiva K. Kolluri, Prasad R. Kopparapu, Martin Pearce
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Abstract
Methods for inducing growth inhibition or apoptosis of Bcl-2-expressing cells and treatments of Bcl-2 expressing cancers are provided. Additionally, assays for agents that can induce apoptosis of Bcl-2 expressing cells are disclosed.
Claims27
A method for inducing growth inhibition or apoptosis of a Bcl-2-expressing cell, comprising contacting a Bcl-2-expressing cell with an agent that exposes the BH3 domain of Bcl-2 thereby converting Bcl-2 into a pro-apoptotic protein and activating the intrinsic apoptosis pathway.
2-5. (canceled)
A method of treating Bcl-2-expressing cancer in a subject, comprising administering to a subject in need of cancer treatment, a therapeutically effective amount of an agent that exposes the BH3 domain of Bcl-2 thereby converting Bcl-2 into a pro-apoptotic protein.
7-10. (canceled)
(canceled)
Dependencies are inferred from the claim text.