Oral amphetamine composition

An orally disintegrating pharmaceutical composition comprising:

• (a) taste-masked drug containing particles comprising:
• (i) drug-containing core particles comprising a therapeutically effective amount of racemic amphetamine, or a pharmaceutically acceptable salt or ester thereof and at least one excipient;
• (ii) a first taste-masking membrane comprising ethylcellulose and excluding pharmaceutically acceptable gastrosoluble polymers, wherein the first taste-masking membrane is disposed on the drug-containing core particles and has a membrane thickness of from about 5% to about 10% by wt. of the taste-masked drug containing particle, and
• (iii) a second taste-masking membrane comprising ethylcellulose and aminoalkyl methacrylate copolymer at a ratio ranging from about 95/5 to about 50/50 by wt., wherein the second taste-masking membrane is disposed on the first taste-masking membrane and the second taste-masking membranes has a thickness of from about 15% to about 30% by wt. of the taste-masked drug containing particle;
• (b) a disintegrant;
• (c) a sugar alcohol or saccharide, or mixture thereof;
• and
• wherein if the orally disintegrating pharmaceutical composition comprises 30 mg of racemic amphetamine sulfate, after administration the orally disintegrating pharmaceutical composition provides one or more of the following:
• an AUCinf ranging from about 80% to about 125% of about 400-600 hr*ng/mL;
• a Cmax ranging from about 80% to about 125% of about 25-35 ng/mL;
• or
• a Tmax ranging from about 80% to about 125% of about 2-4 hrs.